Isolation of constituents and anti-complement activity from Acer okamotoanum

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Title
Isolation of constituents and anti-complement activity from Acer okamotoanum
Author(s)
W Y Jin; B S Min; J P Lee; P T Thuong; Hyeong Kyu Lee; K S Song; Y H Seong; K H Bae
Bibliographic Citation
Archives of Pharmacal Research, vol. 30, no. 2, pp. 172-176
Publication Year
2007
Abstract
A novel acylated sterol glucoside (1) along with four known compounds, β-amyrin acetate (2), 3β,24-dihydroxytaraxer-14-ene (3), cleomiscosin A (4), and cleomiscosin C (5), were isolated from the leaf and twig of Acer okamotoanum Nakai (Aceraceae). The structure of the new compound was determined to be β-sitosterol glucoside-3′-O-hexacosanoicate based on chemical and spectroscopic analyses. In addition, the novel compound was found to exhibit a significant inhibitory effect (IC50 value of 0.2 μM) on the complement system activated by the classical pathway.
Keyword
Acer okamotoanumAceraceaeAcylated sterol glucosideAnti-complement activityβ-Sitosterol glucoside-3′-O-hexacosanoicate
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977691
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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