Stable transcriptional status in the apoptotic erythroid genome

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dc.contributor.authorS Lee-
dc.contributor.authorJ Hwang-
dc.contributor.authorJ Ulaszek-
dc.contributor.authorY C Kim-
dc.contributor.authorH Dong-
dc.contributor.authorH S Kim-
dc.contributor.authorJ W Seok-
dc.contributor.authorB K Suh-
dc.contributor.authorS J Yim-
dc.contributor.authorD Johnson-
dc.contributor.authorN H Choe-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorZ Y Ryoo-
dc.contributor.authorC C Tseng-
dc.contributor.authorA Wickrema-
dc.contributor.authorS M Wang-
dc.date.accessioned2017-04-19T09:07:37Z-
dc.date.available2017-04-19T09:07:37Z-
dc.date.issued2007-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2007.05.168ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7964-
dc.description.abstractWhen a cell is destined for apoptosis, will its genome reprogram its transcriptional machinery to overcome the life-threatening challenge? To address this issue, we performed a genome-wide transcriptome analysis in EPO (erythropoietin) deprivation-induced apoptotic erythroid cells using the SAGE method. The results show that the transcript contents for the majority of the genes remain unchanged in the apoptotic cells, including the apoptotic genes and the heat shock genes. of the small number of genes with an altered expression, they are mainly associated with cellular structure. Our study reveals that there is no genetic reprogramming for the transcriptional machinery in the apoptotic genome. Apoptosis, as defined by programmed cell death, is not a crisis but a peaceful physiological process.-
dc.publisherElsevier-
dc.titleStable transcriptional status in the apoptotic erythroid genome-
dc.title.alternativeStable transcriptional status in the apoptotic erythroid genome-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number3-
dc.citation.endPage562-
dc.citation.startPage556-
dc.citation.volume359-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeName이상규-
dc.contributor.alternativeName황준모-
dc.contributor.alternativeNameUlaszek-
dc.contributor.alternativeName김영-
dc.contributor.alternativeNameDong-
dc.contributor.alternativeName김형수-
dc.contributor.alternativeName석지웅-
dc.contributor.alternativeName서보경-
dc.contributor.alternativeName임소정-
dc.contributor.alternativeNameJohnson-
dc.contributor.alternativeName최농훈-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName류재영-
dc.contributor.alternativeNameTseng-
dc.contributor.alternativeNameWickrema-
dc.contributor.alternativeNameWang-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 359, no. 3, pp. 556-562-
dc.identifier.doi10.1016/j.bbrc.2007.05.168-
dc.subject.keywordapoptosis-
dc.subject.keyworderythroid-
dc.subject.keywordgene expression-
dc.subject.keywordgenome-
dc.subject.keywordSAGE-
dc.subject.keywordtranscription-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localerythroid-
dc.subject.localGene Expression-
dc.subject.localGene expression-
dc.subject.localgene expression-
dc.subject.localgenome-
dc.subject.localGenome-
dc.subject.localSAGE-
dc.subject.localTranscription-
dc.subject.localtranscription-
dc.description.journalClassY-
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