Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B

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dc.contributor.authorMin Kyun Na-
dc.contributor.authorDuc Manh Hoang-
dc.contributor.authorD Njamen-
dc.contributor.authorJ T Mbafor-
dc.contributor.authorZ T Fomum-
dc.contributor.authorP T Thuong-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorWon Keun Oh-
dc.date.accessioned2017-04-19T09:07:37Z-
dc.date.available2017-04-19T09:07:37Z-
dc.date.issued2007-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2007.05.005ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7966-
dc.description.abstractBioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina addisoniae (Leguminosae), using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new (1-3) and three known (4-6) 2-arylbenzofuran derivatives. The new compounds were identified as 2-[2′,4′-dihydroxy-3′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (1), 2-[2′-methoxy-4′-hydroxy-5′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (2), and 2-(2′-methoxy-4′-hydroxyphenyl)-5-(3-methylbut-2-enyl)-6-hydroxybenzofuran (3). The new 2-arylbenzofurans 1-3 inhibited PTP1B activity with IC50 values ranging from 13.6 ± 1.1 to 17.5 ± 1.2 μM in vitro assay. On the basis of the data obtained, 2-arylbenzofurans with prenyl group may be considered as a new class of PTP1B inhibitors.-
dc.publisherElsevier-
dc.titleInhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B-
dc.title.alternativeInhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number14-
dc.citation.endPage3871-
dc.citation.startPage3868-
dc.citation.volume17-
dc.contributor.affiliatedAuthorDuc Manh Hoang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorWon Keun Oh-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeName황덕만-
dc.contributor.alternativeNameNjamen-
dc.contributor.alternativeNameMbafor-
dc.contributor.alternativeNameFomum-
dc.contributor.alternativeNameThuong-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName오원근-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 17, no. 14, pp. 3868-3871-
dc.identifier.doi10.1016/j.bmcl.2007.05.005-
dc.subject.keyword2-Arylbenzofuran derivatives-
dc.subject.keyworderythrina addisoniae-
dc.subject.keywordprenyl group-
dc.subject.keywordprotein tyrosine phosphatase-1B (PTP1B)-
dc.subject.local2-Arylbenzofuran derivatives-
dc.subject.localErythrina addisoniae-
dc.subject.localerythrina addisoniae-
dc.subject.localprenyl group-
dc.subject.localprotein tyrosine phosphatase 1B-
dc.subject.localprotein tyrosine phosphatase-1B (PTP1B)-
dc.subject.localProtein tyrosine phosphatase 1B-
dc.subject.localprotein tyrosine phosphatase 1B (PTP1B)-
dc.subject.localprotein tyrosine phosphatase 1B (FTPIB)-
dc.subject.localProtein tyrosine phosphatase 1B (PTP1B)-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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