DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min Kyun Na | - |
dc.contributor.author | Duc Manh Hoang | - |
dc.contributor.author | D Njamen | - |
dc.contributor.author | J T Mbafor | - |
dc.contributor.author | Z T Fomum | - |
dc.contributor.author | P T Thuong | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.contributor.author | Won Keun Oh | - |
dc.date.accessioned | 2017-04-19T09:07:37Z | - |
dc.date.available | 2017-04-19T09:07:37Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | 10.1016/j.bmcl.2007.05.005 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7966 | - |
dc.description.abstract | Bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina addisoniae (Leguminosae), using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new (1-3) and three known (4-6) 2-arylbenzofuran derivatives. The new compounds were identified as 2-[2′,4′-dihydroxy-3′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (1), 2-[2′-methoxy-4′-hydroxy-5′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (2), and 2-(2′-methoxy-4′-hydroxyphenyl)-5-(3-methylbut-2-enyl)-6-hydroxybenzofuran (3). The new 2-arylbenzofurans 1-3 inhibited PTP1B activity with IC50 values ranging from 13.6 ± 1.1 to 17.5 ± 1.2 μM in vitro assay. On the basis of the data obtained, 2-arylbenzofurans with prenyl group may be considered as a new class of PTP1B inhibitors. | - |
dc.publisher | Elsevier | - |
dc.title | Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B | - |
dc.title.alternative | Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.number | 14 | - |
dc.citation.endPage | 3871 | - |
dc.citation.startPage | 3868 | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Duc Manh Hoang | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.affiliatedAuthor | Won Keun Oh | - |
dc.contributor.alternativeName | 나민균 | - |
dc.contributor.alternativeName | 황덕만 | - |
dc.contributor.alternativeName | Njamen | - |
dc.contributor.alternativeName | Mbafor | - |
dc.contributor.alternativeName | Fomum | - |
dc.contributor.alternativeName | Thuong | - |
dc.contributor.alternativeName | 안종석 | - |
dc.contributor.alternativeName | 오원근 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 14, pp. 3868-3871 | - |
dc.identifier.doi | 10.1016/j.bmcl.2007.05.005 | - |
dc.subject.keyword | 2-Arylbenzofuran derivatives | - |
dc.subject.keyword | erythrina addisoniae | - |
dc.subject.keyword | prenyl group | - |
dc.subject.keyword | protein tyrosine phosphatase-1B (PTP1B) | - |
dc.subject.local | 2-Arylbenzofuran derivatives | - |
dc.subject.local | Erythrina addisoniae | - |
dc.subject.local | erythrina addisoniae | - |
dc.subject.local | prenyl group | - |
dc.subject.local | protein tyrosine phosphatase 1B | - |
dc.subject.local | protein tyrosine phosphatase-1B (PTP1B) | - |
dc.subject.local | Protein tyrosine phosphatase 1B | - |
dc.subject.local | protein tyrosine phosphatase 1B (PTP1B) | - |
dc.subject.local | protein tyrosine phosphatase 1B (FTPIB) | - |
dc.subject.local | Protein tyrosine phosphatase 1B (PTP1B) | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.