The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities

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dc.contributor.authorC H Yun-
dc.contributor.authorK H Kim-
dc.contributor.authorD H Kim-
dc.contributor.authorHeung Chae Jung-
dc.contributor.authorJae Gu Pan-
dc.date.accessioned2017-04-19T09:07:38Z-
dc.date.available2017-04-19T09:07:38Z-
dc.date.issued2007-
dc.identifier.issn0167-7799-
dc.identifier.uri10.1016/j.tibtech.2007.05.003ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7967-
dc.description.abstractThe use of cytochrome P450 (P450 or CYP) enzymes as biocatalysts for the production of fine chemicals, including pharmaceuticals, has been of increasing interest, primarily owing to their catalytic diversity and broad substrate range. CYP102A1 (P450 BM3) from Bacillus megaterium integrates an entire monooxygenase system into one polypeptide and represents an appropriate prokaryotic model for industrial applications of mammalian P450 activities. CYP102A1 not only exhibits the highest catalytic activity ever detected in a P450 monooxygenase but also provides a potentially versatile biocatalyst for the production of human P450 metabolites. CYP102A1 can be further engineered to be a drug-metabolizing enzyme, making it a promising candidate to use as a biocatalyst in drug discovery and synthesis.-
dc.publisherElsevier-
dc.titleThe bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities-
dc.title.alternativeThe bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities-
dc.typeArticle-
dc.citation.titleTrends in Biotechnology-
dc.citation.number7-
dc.citation.endPage298-
dc.citation.startPage289-
dc.citation.volume25-
dc.contributor.affiliatedAuthorHeung Chae Jung-
dc.contributor.affiliatedAuthorJae Gu Pan-
dc.contributor.alternativeName윤철호-
dc.contributor.alternativeName김건희-
dc.contributor.alternativeName김동현-
dc.contributor.alternativeName정흥채-
dc.contributor.alternativeName반재구-
dc.identifier.bibliographicCitationTrends in Biotechnology, vol. 25, no. 7, pp. 289-298-
dc.identifier.doi10.1016/j.tibtech.2007.05.003-
dc.description.journalClassY-
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Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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