Open Access@KRIBBOchang Branch InstituteDivision of National Bio-InfrastructureLaboratory Animal Resource & Research Center1. Journal Articles
Structure-activity relationship studies of a series of novel δ-lactam-based histone deacetylase inhibitors
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- Title
- Structure-activity relationship studies of a series of novel δ-lactam-based histone deacetylase inhibitors
- Author(s)
- Hwan Mook Kim; D K Ryu; Y Choi; Bum Woo Park; Kiho Lee; Sang Bae Han; Chang-Woo Lee; Moo-Rim Kang; Jong Soon Kang; S K Boovanahalli; Song Kyu Park; J W Han; T G Chun; H Y Lee; K Y Nam; E H Choi; G Han
- Bibliographic Citation
- Journal of Medicinal Chemistry, vol. 50, no. 11, pp. 2737-2741
- Publication Year
- 2007
- Abstract
- We synthesized a series of δ-lactam-based HDAC inhibitors that were identified with various degrees of anti-inflammatory and cell growth inhibitory activities. Compounds possessing significant HDAC inhibitory activity exhibited both anti-inflammatory and cell growth inhibitory activities as well as significant tumor growth inhibition in the in vivo tumor xenograft experiments. Besides, these compounds demonstrated antiinflammatory properties in vitro via suppression of the production of the proinflammatory cytokine TNF-α and nitric oxide by LPS-stimulated RAW264.7 cells.
- ISSN
- 0022-2623
- Publisher
- Amer Chem Soc
- Full Text Link
- http://dx.doi.org/10.1021/jm0613828
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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