Structure-activity relationship studies of a series of novel δ-lactam-based histone deacetylase inhibitors

Cited 30 time in scopus
Metadata Downloads
Title
Structure-activity relationship studies of a series of novel δ-lactam-based histone deacetylase inhibitors
Author(s)
Hwan Mook Kim; D K Ryu; Y Choi; Bum Woo Park; Kiho Lee; Sang Bae Han; Chang-Woo Lee; Moo-Rim Kang; Jong Soon Kang; S K Boovanahalli; Song Kyu Park; J W Han; T G Chun; H Y Lee; K Y Nam; E H Choi; G Han
Bibliographic Citation
Journal of Medicinal Chemistry, vol. 50, no. 11, pp. 2737-2741
Publication Year
2007
Abstract
We synthesized a series of δ-lactam-based HDAC inhibitors that were identified with various degrees of anti-inflammatory and cell growth inhibitory activities. Compounds possessing significant HDAC inhibitory activity exhibited both anti-inflammatory and cell growth inhibitory activities as well as significant tumor growth inhibition in the in vivo tumor xenograft experiments. Besides, these compounds demonstrated antiinflammatory properties in vitro via suppression of the production of the proinflammatory cytokine TNF-α and nitric oxide by LPS-stimulated RAW264.7 cells.
ISSN
0022-2623
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/jm0613828
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.