Inhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa = 비목나무로부터 분리한 리그난 화합물의 키틴 합성효소 2의 저해 및 항진균 활성

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Title
Inhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa = 비목나무로부터 분리한 리그난 화합물의 키틴 합성효소 2의 저해 및 항진균 활성
Author(s)
E I Hwang; Y M Lee; Sang Myung Lee; W H Yeo; Jae Sun Moon; Tae Hoon Kang; K D Park; Sung Uk Kim
Bibliographic Citation
Planta Medica, vol. 73, no. 7, pp. 679-682
Publication Year
2007
Abstract
Potent chitin synthase 2 inhibitors, methyllinderone (1), linderone (2) and kanakugiol (3) were isolated from the stem bark of L. erythrocarpa Makino (Lauraceae). These compounds inhibited chitin synthase 2 with IC50 values of 23.3, 21.4 and 23.8 μg/mL, respectively. Methyllinderone (1) and linderone (2) exhibited no inhibitory activities for chitin synthases 1 and 3 from S. cerevisiae, and chitin synthase 1 from Candida albicans up to the concentration of 280 μg/mL, while kanakugiol (3) exhibited very weak activity against chitin synthase 1 of C. albicans with an IC50 of 160 μg/mL. All of the compounds showed moderate to weak antifungal activities against various pathogenic fungi (MIC: 8 → 128 μg/mL) including Cryptococcus neoformans, Aspergillus fumigatus, and Colletotrichum lagenarium. The results indicate that these compounds are specific inhibitors of chitin synthase 2 and can potentially serve as antifungal agents.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2007-981526
Type
Article
Appears in Collections:
Division of Biomaterials Research > Plant Systems Engineering Research > 1. Journal Articles
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