Inhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa = 비목나무로부터 분리한 리그난 화합물의 키틴 합성효소 2의 저해 및 항진균 활성

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dc.contributor.authorE I Hwang-
dc.contributor.authorY M Lee-
dc.contributor.authorSang Myung Lee-
dc.contributor.authorW H Yeo-
dc.contributor.authorJae Sun Moon-
dc.contributor.authorTae Hoon Kang-
dc.contributor.authorK D Park-
dc.contributor.authorSung Uk Kim-
dc.date.accessioned2017-04-19T09:07:41Z-
dc.date.available2017-04-19T09:07:41Z-
dc.date.issued2007-
dc.identifier.issn00320943-
dc.identifier.uri10.1055/s-2007-981526ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7984-
dc.description.abstractPotent chitin synthase 2 inhibitors, methyllinderone (1), linderone (2) and kanakugiol (3) were isolated from the stem bark of L. erythrocarpa Makino (Lauraceae). These compounds inhibited chitin synthase 2 with IC50 values of 23.3, 21.4 and 23.8 μg/mL, respectively. Methyllinderone (1) and linderone (2) exhibited no inhibitory activities for chitin synthases 1 and 3 from S. cerevisiae, and chitin synthase 1 from Candida albicans up to the concentration of 280 μg/mL, while kanakugiol (3) exhibited very weak activity against chitin synthase 1 of C. albicans with an IC50 of 160 μg/mL. All of the compounds showed moderate to weak antifungal activities against various pathogenic fungi (MIC: 8 → 128 μg/mL) including Cryptococcus neoformans, Aspergillus fumigatus, and Colletotrichum lagenarium. The results indicate that these compounds are specific inhibitors of chitin synthase 2 and can potentially serve as antifungal agents.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleInhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa = 비목나무로부터 분리한 리그난 화합물의 키틴 합성효소 2의 저해 및 항진균 활성-
dc.title.alternativeInhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number7-
dc.citation.endPage682-
dc.citation.startPage679-
dc.citation.volume73-
dc.contributor.affiliatedAuthorJae Sun Moon-
dc.contributor.alternativeName황의일-
dc.contributor.alternativeName이윤미-
dc.contributor.alternativeName이상명-
dc.contributor.alternativeName여운형-
dc.contributor.alternativeName문제선-
dc.contributor.alternativeName강태훈-
dc.contributor.alternativeName박기덕-
dc.contributor.alternativeName김성욱-
dc.identifier.bibliographicCitationPlanta Medica, vol. 73, no. 7, pp. 679-682-
dc.identifier.doi10.1055/s-2007-981526-
dc.description.journalClassY-
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Division of Biomaterials Research > Plant Systems Engineering Research > 1. Journal Articles
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