Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis

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Title
Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis
Author(s)
T M Hung; Min Kyun Na; B S Min; T M Ngoc; I Lee; X Zhang; K Bae
Bibliographic Citation
Archives of Pharmacal Research, vol. 30, no. 6, pp. 685-690
Publication Year
2007
Abstract
The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies, fourteen lignans were isolated, and evaluated for their inhibitory effect on AChE. The compounds having both aromatic methylenedioxy and hydroxyl groups on their cyclooctadiene ring, such as gomisin C (6), gomisin G (7), gomisin D (8), schisandrol B (11) and gomisin A (13), entirely inhibited AChE in dose dependent manners, with IC50 values of 6.71 ± 0.53, 6.55 ± 0.31, 7.84 ± 0.62, 12.57 ± 1.07 and 13.28 ± 1.68 μM, respectively. These results indicate that the lignans could potentially be a potent class of AChE inhibitors.
Keyword
Acetylcholinesterase (AChE)Alzheimer's diseaseGomisinSchisandrinSchizandra chinensisWuweizisu
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977628
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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