Isoprenylated flavonoids from the stem bark of Erythrina abyssinica

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Title
Isoprenylated flavonoids from the stem bark of Erythrina abyssinica
Author(s)
L Cui; D T Ndinteh; M K Na; P T Thuong; J S Muruumu; D Njamen; J T Mbafor; Z T Fomum; Jong Seog Ahn; Won Keun Oh
Bibliographic Citation
Journal of Natural Products, vol. 70, no. 6, pp. 1039-1042
Publication Year
2007
Abstract
Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 14.2 ± 1.7 to 26.7 ± 1.2 μM.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np060477+
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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