Antifungal cyclopeptolide from fungal saprophytic antagonist Ulocladium atrum

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Antifungal cyclopeptolide from fungal saprophytic antagonist Ulocladium atrum
Bong Sik Yun; E M Kwon; J C Kim; S H Yu
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 17, no. 7, pp. 1217-1220
Publication Year
The saprophytic fungus Ulocladium atrum Preuss is a promising biological control agent for Botrytis cinerea in greenhouse- and field-grown crops. However, despite its known potent antifungal activity, no antifungal substance has yet been reported. In an effort to characterize the antifungal substance from U atrum, we isolated an antibiotic peptide. Based on extensive spectroscopic analyses, its structure was established as a cyclopeptolide with a high portion of N-methylated amino acids, and its 1H and 13C chemical shifts were completely assigned based on extensive 1D and 2D NMR experiments. Compound 1 exhibited potent antifungal activity against the plant pathogenic fungus Botrytis cinerea and moderate activity against Alternaria alternate and Magnaporthe grisea.
antifungal agentsascomycotamolecular structurenuclear magnetic resonance, biomolecularpeptides, cyclic
Korea Soc-Assoc-Inst
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