Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1

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dc.contributor.authorN T Dat-
dc.contributor.authorX Jin-
dc.contributor.authorJ H Lee-
dc.contributor.authorD Lee-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorKyeong Lee-
dc.contributor.authorY H Kim-
dc.contributor.authorJung Joon Lee-
dc.date.accessioned2017-04-19T09:07:46Z-
dc.date.available2017-04-19T09:07:46Z-
dc.date.issued2007-
dc.identifier.issn01633864-
dc.identifier.uri10.1021/np060482dko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8016-
dc.description.abstractThe hypoxia-inducible factor-1 (HIF-1) has been known to be correlated to the adaptation and proliferation of tumor cells; therefore HIF-1 has become an important target in the development of anticancer drugs. A phytochemical study of the CHCl3-soluble fraction of Salvia miltiorrhiza, which strongly inhibited hypoxia-induced reporter gene expression, led to the isolation of 12 abietane-type diterpenes. of these compounds, sibiriquinone A (1), sibiriquinone B (2), cryptotanshinone (3), and dihydrotanshinone I (4) potently inhibited hypoxia-induced luciferase expression with IC50 values of 0.34, 3.36, 1.58, and 2.05 μM on AGS cells, a human gastric cancer cell line, and 0.28, 3.18, 1.36, and 2.29 μM on Hep3B cells, a human hepatocarcinoma cell line, respectively. Consistently, 1 and 4 dose-dependently suppressed the HIF-1α accumulation and 1 inhibited mRNA expression of vascular endothelial growth factor (VEGF) under hypoxia. These results suggest that the anticancer activity of tanshinones is likely at least in part associated with their inhibition of HIF-1 accumulation.-
dc.publisherAmer Chem Soc-
dc.titleAbietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1-
dc.title.alternativeAbietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number7-
dc.citation.endPage1097-
dc.citation.startPage1093-
dc.citation.volume70-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.alternativeNameDat-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName이정형-
dc.contributor.alternativeName이동호-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName이정준-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 70, no. 7, pp. 1093-1097-
dc.identifier.doi10.1021/np060482d-
dc.description.journalClassY-
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Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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