Development of natural killer cells from hematopoietic stem cells

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dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorJin Woong Chung-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:07:50Z-
dc.date.available2017-04-19T09:07:50Z-
dc.date.issued2007-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8040-
dc.description.abstractNatural killer (NK) cells play a crucial role in innate immune system and tumor surveillance. NK cells are derived from CD34+hematopoietic stem cells and undergo differentiation via precursor NK cells in bone marrow (BM) through sequential acquisition of functional surface receptors. During differentiation of NK cells, many factors are involved including cytokines, membrane factors and transcription factors as well as microenvironment of BM. NK cells express their own repertoire of receptors including activating and inhibitory receptors that bind to major histocompatibility complex (MHC) class I or class I-related molecules. The balance between activating and inhibitory receptors determines the function of NK cells to kill targets. Binding of NK cell inhibitory receptors to their MHC class I-ligand renders the target cells to be protected from NK cell-mediated cytotoxicity. Thus, NK cells are able to discriminate self from non-self through MHC class I-binding inhibitory receptor. Using intrinsic properties of NK cells, NK cells are emerging to apply as therapeutic agents against many types of cancers. Recently, NK cell alloactivity has also been exploited in killer cell immunoglobulin-like receptor mismatched haploidentical stem cell transplantation to reduce the rate of relapse and graft versus host disease. In this review, we discuss the basic mechanisms of NK cell differentiation, diversity of NK cell receptors, and clinical applications of NK cells for anti-cancer immunotherapy.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleDevelopment of natural killer cells from hematopoietic stem cells-
dc.title.alternativeDevelopment of natural killer cells from hematopoietic stem cells-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number1-
dc.citation.endPage8-
dc.citation.startPage1-
dc.citation.volume24-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorJin Woong Chung-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName정진웅-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 24, no. 1, pp. 1-8-
dc.subject.keywordhematopoietic stem cells-
dc.subject.keywordnatural killer cell differentiation-
dc.subject.keywordNK cell therapy-
dc.subject.keywordNK receptor repertoire-
dc.subject.localhematopoietic stem cells-
dc.subject.localnatural killer cell differentiation-
dc.subject.localNK cell therapy-
dc.subject.localNK receptor repertoire-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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