Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model

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dc.contributor.authorMee Young Lee-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorOk Kyung Kwon-
dc.contributor.authorM J Kim-
dc.contributor.authorM K Kim-
dc.contributor.authorI Y Lee-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T09:07:52Z-
dc.date.available2017-04-19T09:07:52Z-
dc.date.issued2007-
dc.identifier.issn0171-2985-
dc.identifier.uri10.1016/j.imbio.2007.05.004ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8053-
dc.description.abstractKefir is a microbial symbiont mixture that produces jelly-like grains. As a widely used neutraceutical, however, the therapeutic applicabilityof kefir is not certain. In order to investigate the pharmacological effects of kefir, we used a mouse asthma model, in which airway inflammation and airway remodeling was produced by ovalbumin sensitization and challenge. BALB/c mice sensitized and challenged to ovalbumin, were treated with kefir (50 mg/kg administered by intra-gastric mode) 1 h before the ovalbumin challenge. Kefir significantly suppressed ovalbumin-induced airway hyper-responsiveness (AHR) to inhaled methacholine. Intra-gastric administration of kefir significantly inhibited the increase in the total inflammatory cell count induced by ovalbumin, and the eosinophil count in bronchoalveolar lavage fluid (BALF). Type 2 helper T cell (Th2) cytokines, such as interleukin-4 and interleukin-13, and total immunoglobulin E (Ig E) levels, were also reduced to normal levels in bronchoalveolar lavage fluid. Histological studies demonstrate that kefir substantially inhibited ovalbumin-induced eosinophilia in lung tissue and mucus hyper-secretion by goblet cells in the airway. Kefir displayed anti-inflammatory and anti-allergic effects in a mouse asthma model and may possess new therapeutic potential for the treatment of allergic bronchial asthma.-
dc.publisherElsevier-
dc.titleAnti-inflammatory and anti-allergic effects of kefir in a mouse asthma model-
dc.title.alternativeAnti-inflammatory and anti-allergic effects of kefir in a mouse asthma model-
dc.typeArticle-
dc.citation.titleImmunobiology-
dc.citation.number8-
dc.citation.endPage654-
dc.citation.startPage647-
dc.citation.volume212-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorOk Kyung Kwon-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName이미영-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName김미진-
dc.contributor.alternativeName김미경-
dc.contributor.alternativeName이인영-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationImmunobiology, vol. 212, no. 8, pp. 647-654-
dc.identifier.doi10.1016/j.imbio.2007.05.004-
dc.subject.keywordAirway hyper-responsiveness-
dc.subject.keywordAsthma-
dc.subject.keywordInflammation-
dc.subject.keywordKefir-
dc.subject.keywordMucus hyper-secretion-
dc.subject.keywordOvalbumin-induced mouse model-
dc.subject.localairway hyperresponsiveness-
dc.subject.localAirway hyper-responsiveness-
dc.subject.localAirway hyperresponsiveness-
dc.subject.localasthma-
dc.subject.localAsthma-
dc.subject.localinflammation-
dc.subject.localInflammation-
dc.subject.localKefir-
dc.subject.localMucus hyper-secretion-
dc.subject.localmucus hypersecretion-
dc.subject.localMucus hypersecretion-
dc.subject.localOvalbumin-induced mouse model-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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