Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents = 신남알데하이드 신규 골격의 유도체의 합성 및 항암활성 기전 규명

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dc.contributor.authorDae Seop Shin-
dc.contributor.authorJ Kim-
dc.contributor.authorDong Cho Han-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorS H Hong-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T09:07:52Z-
dc.date.available2017-04-19T09:07:52Z-
dc.date.issued2007-
dc.identifier.issn0960894X-
dc.identifier.uri10.1016/j.bmcl.2007.07.033ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8054-
dc.description.abstractA series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.-
dc.publisherElsevier-
dc.titleSynthesis and biological evaluation of cinnamyl compounds as potent antitumor agents = 신남알데하이드 신규 골격의 유도체의 합성 및 항암활성 기전 규명-
dc.title.alternativeSynthesis and biological evaluation of cinnamyl compounds as potent antitumor agents-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number19-
dc.citation.endPage5427-
dc.citation.startPage5423-
dc.citation.volume17-
dc.contributor.affiliatedAuthorDong Cho Han-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName신대섭-
dc.contributor.alternativeName김지인-
dc.contributor.alternativeName한동초-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName홍수형-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 17, no. 19, pp. 5423-5427-
dc.identifier.doi10.1016/j.bmcl.2007.07.033-
dc.subject.keywordapoptosis-
dc.subject.keywordcell cycle-
dc.subject.keywordcinnamaldehyde-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localcell cycle-
dc.subject.localCell cycle-
dc.subject.localcinnamaldehyde-
dc.subject.localCinnamaldehyde-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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