Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring

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Title
Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring
Author(s)
Won Cheol Kim; Jong Suk Lee; D Lee; X F Cai; J C Shin; Kyeong Lee; C H Lee; S Ryu; S G Paik; Jung Joon Lee; Young-Soo Hong
Bibliographic Citation
Chembiochem, vol. 8, no. 13, pp. 1491-1494
Publication Year
2007
Abstract
(Chemical Equation Presented) A not so familiar ring. We describe results obtained from a mutasynthetic study based on geldanamycin (1), and demonstrate that this technique can be used to extend the structural diversity of the benzoquinone ring of 1. Our results show that geldanamycin PKS modules tolerate polyketide intermediate chains that bear unnatural benzoate components, and that they extend these structures further to produce mature polyketides (see scheme).
Keyword
AnsamycinAntitumor agentsGeldanamycinMutasynthesisPolyketides
ISSN
1439-4227
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/cbic.200700196
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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