The role of Hansenula polymorpha MIG1 homologues in catabolite repression and pexophagy

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Title
The role of Hansenula polymorpha MIG1 homologues in catabolite repression and pexophagy
Author(s)
O G Stasyk; T Zutphen; Hyun Ah Kang; O V Stasyk; M Veenhuis; A A Sibirny
Bibliographic Citation
FEMS Yeast Research, vol. 7, no. 7, pp. 1103-1113
Publication Year
2007
Abstract
In the methanol-utilizing yeast Hansenula polymorpha, glucose and ethanol trigger the repression of peroxisomal enzymes at the transcriptional level, and rapid and selective degradation of methanol-induced peroxisomes by means of a process termed pexophagy. In this report we demonstrate that deficiency in the putative H. polymorpha homologues of transcriptional repressors Mig1 (HpMig1 and HpMig2), as well as HpTup1, partially and differentially affects the repression of peroxisomal alcohol oxidase by sugars and ethanol. As reported earlier, deficiency in HpTup1 leads to impairment of glucose- or ethanol-induced macropexophagy. In H. polymorpha mig1mig2 double-deletion cells, macropexophagy was also substantially impaired, whereas micropexophagy became a dominant mode of autophagic degradation. Our findings suggest that homologues of the elements of the Saccharomyces cerevisiae main repression pathway have pleiotropic functions in H. polymorpha.
Keyword
catabolite repressionhansenula polymorphapexophagytranscriptional repressorsyeast
ISSN
1567-1356
Publisher
Oxford Univ Press
DOI
http://dx.doi.org/10.1111/j.1567-1364.2007.00286.x
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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