Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway = GTP-Ras 의존형 경로와 밀접하게 연관되어 있는 천마의 항암활성

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dc.contributor.authorJ C Heo-
dc.contributor.authorS U Woo-
dc.contributor.authorM Son-
dc.contributor.authorJ Y Park-
dc.contributor.authorWon Sik Choi-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorSung Uk Kim-
dc.contributor.authorE K Yoon-
dc.contributor.authorY H Kim-
dc.contributor.authorH M Shin-
dc.contributor.authorS H Lee-
dc.date.accessioned2017-04-19T09:08:02Z-
dc.date.available2017-04-19T09:08:02Z-
dc.date.issued2007-
dc.identifier.issn1021335X-
dc.identifier.uri10.3892/or.18.4.849ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8078-
dc.description.abstractGastrodia elata Blume (GEB) is an important medicinal plant in Korea. In order to confirm the anti-tumor activities of GEB extracts, we carried out various in vitro anti-tumor assays, including a wound assay and an invasion assay using an ethyl ether extract of GEB. The results showed that the GEB extract exhibits potent anti-tumor activity in vitro in a dose-dependent manner. The expression of CD44, cdc42, Timp-2 or RhoA mRNA did not change by GEB treatment, compared to that of the control. GTP-Ras, an active form of a G-coupled protein family, however, is associated with the anti-tumor activity of GEB extracts. We examined various molecular markers related to metastasis by reverse transcriptase-polymerase chain reaction with the extract of GEB-treated B16 cells. There was an increase in GTP-Ras expression by the Gastrodia elata Blume extract. Together, these results suggest that the Gastrodia elata Blume extract could have potential in alleviating tumorigenesis, by a GTP-Ras-dependent pathway; although the precise molecular mechanisms are still being examined.-
dc.publisherSpandidos Publ Ltd-
dc.titleAnti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway = GTP-Ras 의존형 경로와 밀접하게 연관되어 있는 천마의 항암활성-
dc.title.alternativeAnti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway-
dc.typeArticle-
dc.citation.titleOncology Reports-
dc.citation.number4-
dc.citation.endPage853-
dc.citation.startPage849-
dc.citation.volume18-
dc.contributor.alternativeName허진철-
dc.contributor.alternativeName우상욱-
dc.contributor.alternativeName손민식-
dc.contributor.alternativeName박자영-
dc.contributor.alternativeName최원식-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName김성욱-
dc.contributor.alternativeName윤은경-
dc.contributor.alternativeName김용훈-
dc.contributor.alternativeName신흥묵-
dc.contributor.alternativeName이상한-
dc.identifier.bibliographicCitationOncology Reports, vol. 18, no. 4, pp. 849-853-
dc.identifier.doi10.3892/or.18.4.849-
dc.subject.keywordAnti-tumor-
dc.subject.keywordB16 melanoma cells-
dc.subject.keywordGastrodia elata Blume-
dc.subject.keywordGTP-Ras-dependent pathway-
dc.subject.localAnti-tumor-
dc.subject.localAntitumor-
dc.subject.localB16 melanoma cells-
dc.subject.localGastrodia elata Blume-
dc.subject.localgastrodia elata blume-
dc.subject.localGTP-Ras-dependent pathway-
dc.description.journalClassY-
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