Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation

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dc.contributor.authorY L Choi-
dc.contributor.authorJ Kim-
dc.contributor.authorM J Kwon-
dc.contributor.authorJ S Choi-
dc.contributor.authorT J Kim-
dc.contributor.authorD S Bae-
dc.contributor.authorSang Seok Koh-
dc.contributor.authorY H In-
dc.contributor.authorYoung Woo Park-
dc.contributor.authorS H Kim-
dc.contributor.authorG Ahn-
dc.contributor.authorY K Shin-
dc.date.accessioned2017-04-19T09:08:14Z-
dc.date.available2017-04-19T09:08:14Z-
dc.date.issued2007-
dc.identifier.issn0213-3911-
dc.identifier.uri10.14670/HH-22.1185ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8090-
dc.description.abstractTight junction proteins claudin 3 (CLDN3) and claudin 4 (CLDN4) are frequently altered in several human cancers, including ovarian carcinomas. Here, we examined the gene expression of CLDN3 and CLDN4 in various tumors, including 19 normal ovaries and 47 ovarian carcinomas by analyzing Affymetrix HG-U133 array data. Furthermore, a total of 114 ovarian serous tumors, including 10 adenomas, 20 borderline tumors and 84 carcinomas, were analyzed immunohistochemically to confirm the expression of two proteins and we assessed the association of their expression with the clinicopathological characteristics and survival of the patients. The microarray experiment revealed CLDN3 and CLDN4 transcripts were significantly up-regulated by 5-fold or more in most subtypes of ovarian epithelial carcinomas while the immunohistochemical analyses indicated that each protein was expressed in 68 (81.0%) and 72 (85.7%) of 84 serous adenocarcinomas, respectively. Borderline serous tumors and adenomas showed significantly lower expression of these proteins than the adenocarcinomas. Kaplan-Meier survival analysis showed that serous adenocarcinoma patients with high CLDN3 expression had substantially shorter survival (P=0.027). Multivariate analysis demonstrated that CLDN3 overexpression is an independent negative prognostic factor. Our findings suggest that CLDN3 overexpression can be used as a prognostic indicator in ovarian serous carcinomas. Moreover, CLDN3 may be a promising target for antibody-based therapy of ovarian carcinomas ?-
dc.publisherF Hernandez-
dc.titleExpression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation-
dc.title.alternativeExpression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation-
dc.typeArticle-
dc.citation.titleHistology and Histopathology-
dc.citation.number10-
dc.citation.endPage1195-
dc.citation.startPage1185-
dc.citation.volume22-
dc.contributor.affiliatedAuthorSang Seok Koh-
dc.contributor.affiliatedAuthorYoung Woo Park-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName고상석-
dc.contributor.alternativeName-
dc.contributor.alternativeName박영우-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName신영기-
dc.identifier.bibliographicCitationHistology and Histopathology, vol. 22, no. 10, pp. 1185-1195-
dc.identifier.doi10.14670/HH-22.1185-
dc.subject.keywordclaudin 3-
dc.subject.keywordclaudin 4-
dc.subject.keywordovarian serous tumor-
dc.subject.keywordtight junction-
dc.subject.localclaudin 3-
dc.subject.localclaudin-4-
dc.subject.localclaudin 4-
dc.subject.localovarian serous tumor-
dc.subject.localtight junction-
dc.description.journalClassY-
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