Dynamic DNA methylation reprogramming: Active demethylation and immediate remethylation in the male pronucleus of bovine zygotes

Cited 92 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJung Sun Park-
dc.contributor.authorYoung Sun Jeong-
dc.contributor.authorS T Shin-
dc.contributor.authorKyung Kwang Lee-
dc.contributor.authorYong-Kook Kang-
dc.date.accessioned2017-04-19T09:08:15Z-
dc.date.available2017-04-19T09:08:15Z-
dc.date.issued2007-
dc.identifier.issn1058-8388-
dc.identifier.uri10.1002/dvdy.21278ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8096-
dc.description.abstractDNA methylation reprogramming (DMR) is believed to be a key process by which mammalian zygotes gain nuclear totipotency through erasing epigenetic modifications acquired during gametogenesis. Nonetheless, DMR patterns do not seem to be conserved among mammals. To identify uniform rules underlying mammalian DMRs, we explored DMRs of diverse mammalian zygotes. of the zygotes studied, of particular interest was the bovine zygote; the paternal DNA methylation first decreased and was then rapidly restored almost to the maternal methylation level even before the two-cell stage. The 5-azadeoxycytidine treatment led to complete demethylation of the male pronucleus. The unusually dramatic changes in DNA methylation levels indicate that the bovine male pronucleus undergoes active demethylation, which is followed by de novo methylation. Our results show that, in bovine, the compound processes of active DNA demethylation and de novo DNA methylation, along with de novo H3-K9 trimethylation also, take place altogether within this very narrow window of pronucleus development.-
dc.publisherWiley-
dc.titleDynamic DNA methylation reprogramming: Active demethylation and immediate remethylation in the male pronucleus of bovine zygotes-
dc.title.alternativeDynamic DNA methylation reprogramming: Active demethylation and immediate remethylation in the male pronucleus of bovine zygotes-
dc.typeArticle-
dc.citation.titleDevelopmental Dynamics-
dc.citation.number9-
dc.citation.endPage2533-
dc.citation.startPage2523-
dc.citation.volume236-
dc.contributor.affiliatedAuthorJung Sun Park-
dc.contributor.affiliatedAuthorYoung Sun Jeong-
dc.contributor.affiliatedAuthorKyung Kwang Lee-
dc.contributor.affiliatedAuthorYong-Kook Kang-
dc.contributor.alternativeName박정선-
dc.contributor.alternativeName정영선-
dc.contributor.alternativeName신상태-
dc.contributor.alternativeName이경광-
dc.contributor.alternativeName강용국-
dc.identifier.bibliographicCitationDevelopmental Dynamics, vol. 236, no. 9, pp. 2523-2533-
dc.identifier.doi10.1002/dvdy.21278-
dc.subject.keywordActive demethylation-
dc.subject.keywordBovine embryo-
dc.subject.keywordDe novo methylation-
dc.subject.keywordDNA methylation-
dc.subject.keywordEpigenetic-
dc.subject.keywordHistone methylation-
dc.subject.keywordMale pronucleus-
dc.subject.keywordReprogramming-
dc.subject.localactive demethylation-
dc.subject.localActive demethylation-
dc.subject.localBovine embryo-
dc.subject.localBovine Embryo-
dc.subject.localBovine embryos-
dc.subject.localDe novo methylation-
dc.subject.localDNA methylation-
dc.subject.localDNAmethylation-
dc.subject.localepigenetic-
dc.subject.localEpigenetics-
dc.subject.localEpigenetic-
dc.subject.localepigenetics-
dc.subject.localhistone methylation-
dc.subject.localHistone methylation-
dc.subject.localMale pronucleus-
dc.subject.localreprogramming-
dc.subject.localReprogramming-
dc.description.journalClassY-
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.