DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seung-Wook Chi | - |
dc.contributor.author | Do-heyoung Kim | - |
dc.contributor.author | Si Hyung Lee | - |
dc.contributor.author | I Chang | - |
dc.contributor.author | Kyou Hoon Han | - |
dc.date.accessioned | 2017-04-19T09:08:17Z | - |
dc.date.available | 2017-04-19T09:08:17Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0961-8368 | - |
dc.identifier.uri | 10.1110/ps.072983507 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8106 | - |
dc.description.abstract | The preS1 surface antigen of hepatitis B virus (HBV) is known to play an important role in the initial attachment of HBV to hepatocytes. We have characterized structural features of the full-length preS1 using heteronuclear NMR methods and discovered that this 119-residue protein is inherently unstructured without a unique tertiary structure under a nondenaturing condition. Yet, combination of various NMR parameters shows that the preS1 contains "pre-structured" domains broadly covering its functional domains. The most prominent domain is formed by residues 27-45 and overlaps with the putative hepatocyte-binding domain (HBD) encompassing residues 21-47, within which two well-defined pre-structured motifs, formed by Pro 32-Ala36 and Pro41-Phe45 are found. Additional, somewhat less prominent, pre-structured motifs are also formed by residues 11-18, 22-25, 37-40, and 46-50. Overall results suggest that the preS1 is a natively unstructured protein (NUP) whose N-terminal 50 residues, populated with multiple pre-structured motifs, contribute critically to hepatocyte binding. | - |
dc.publisher | Wiley | - |
dc.title | Pre-structured motifs in the natively unstructured preS1 surface antigen of hepatitis B virus | - |
dc.title.alternative | Pre-structured motifs in the natively unstructured preS1 surface antigen of hepatitis B virus | - |
dc.type | Article | - |
dc.citation.title | Protein Science | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 2117 | - |
dc.citation.startPage | 2108 | - |
dc.citation.volume | 16 | - |
dc.contributor.affiliatedAuthor | Seung-Wook Chi | - |
dc.contributor.affiliatedAuthor | Do-heyoung Kim | - |
dc.contributor.affiliatedAuthor | Si Hyung Lee | - |
dc.contributor.affiliatedAuthor | Kyou Hoon Han | - |
dc.contributor.alternativeName | 지승욱 | - |
dc.contributor.alternativeName | 김도형 | - |
dc.contributor.alternativeName | 이시형 | - |
dc.contributor.alternativeName | 장익수 | - |
dc.contributor.alternativeName | 한규훈 | - |
dc.identifier.bibliographicCitation | Protein Science, vol. 16, no. 10, pp. 2108-2117 | - |
dc.identifier.doi | 10.1110/ps.072983507 | - |
dc.subject.keyword | hepatitis B virus | - |
dc.subject.keyword | natively unstructured protein | - |
dc.subject.keyword | NMR | - |
dc.subject.keyword | pre-structured motif | - |
dc.subject.keyword | preS1 | - |
dc.subject.local | hepatitis B virus (HBV) | - |
dc.subject.local | Hepatitis B Virus | - |
dc.subject.local | Hepatitis B virus (HBV) | - |
dc.subject.local | hepatitis B virus | - |
dc.subject.local | hepatitis B Virus (HBV) | - |
dc.subject.local | Hepatitis B virus | - |
dc.subject.local | natively unstructured protein | - |
dc.subject.local | NMR | - |
dc.subject.local | nuclear magnetic resonance (Nmr) | - |
dc.subject.local | Nuclear magnetic resonance | - |
dc.subject.local | nuclear magnetic resonance | - |
dc.subject.local | Nuclear magnetic resonance (NMR) | - |
dc.subject.local | PreSMos (Pre-Structured Motifs) | - |
dc.subject.local | Pre-structured motif | - |
dc.subject.local | Prestructured motif (PreSMo) | - |
dc.subject.local | Pre-structured motif (PreSMo) | - |
dc.subject.local | PreSMo (Pre-Structured Motif) | - |
dc.subject.local | pre-structured motif | - |
dc.subject.local | pre-structured motifs (PreSMos) | - |
dc.subject.local | Pre-Structured Motif (PreSMo) | - |
dc.subject.local | PreSMo | - |
dc.subject.local | PreSMos (pre-structured motifs) | - |
dc.subject.local | PreS1 | - |
dc.subject.local | preS1 | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.