Pre-structured motifs in the natively unstructured preS1 surface antigen of hepatitis B virus

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dc.contributor.authorSeung-Wook Chi-
dc.contributor.authorDo-heyoung Kim-
dc.contributor.authorSi Hyung Lee-
dc.contributor.authorI Chang-
dc.contributor.authorKyou Hoon Han-
dc.date.accessioned2017-04-19T09:08:17Z-
dc.date.available2017-04-19T09:08:17Z-
dc.date.issued2007-
dc.identifier.issn0961-8368-
dc.identifier.uri10.1110/ps.072983507ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8106-
dc.description.abstractThe preS1 surface antigen of hepatitis B virus (HBV) is known to play an important role in the initial attachment of HBV to hepatocytes. We have characterized structural features of the full-length preS1 using heteronuclear NMR methods and discovered that this 119-residue protein is inherently unstructured without a unique tertiary structure under a nondenaturing condition. Yet, combination of various NMR parameters shows that the preS1 contains "pre-structured" domains broadly covering its functional domains. The most prominent domain is formed by residues 27-45 and overlaps with the putative hepatocyte-binding domain (HBD) encompassing residues 21-47, within which two well-defined pre-structured motifs, formed by Pro 32-Ala36 and Pro41-Phe45 are found. Additional, somewhat less prominent, pre-structured motifs are also formed by residues 11-18, 22-25, 37-40, and 46-50. Overall results suggest that the preS1 is a natively unstructured protein (NUP) whose N-terminal 50 residues, populated with multiple pre-structured motifs, contribute critically to hepatocyte binding.-
dc.publisherWiley-
dc.titlePre-structured motifs in the natively unstructured preS1 surface antigen of hepatitis B virus-
dc.title.alternativePre-structured motifs in the natively unstructured preS1 surface antigen of hepatitis B virus-
dc.typeArticle-
dc.citation.titleProtein Science-
dc.citation.number10-
dc.citation.endPage2117-
dc.citation.startPage2108-
dc.citation.volume16-
dc.contributor.affiliatedAuthorSeung-Wook Chi-
dc.contributor.affiliatedAuthorDo-heyoung Kim-
dc.contributor.affiliatedAuthorSi Hyung Lee-
dc.contributor.affiliatedAuthorKyou Hoon Han-
dc.contributor.alternativeName지승욱-
dc.contributor.alternativeName김도형-
dc.contributor.alternativeName이시형-
dc.contributor.alternativeName장익수-
dc.contributor.alternativeName한규훈-
dc.identifier.bibliographicCitationProtein Science, vol. 16, no. 10, pp. 2108-2117-
dc.identifier.doi10.1110/ps.072983507-
dc.subject.keywordhepatitis B virus-
dc.subject.keywordnatively unstructured protein-
dc.subject.keywordNMR-
dc.subject.keywordpre-structured motif-
dc.subject.keywordpreS1-
dc.subject.localhepatitis B virus (HBV)-
dc.subject.localHepatitis B Virus-
dc.subject.localHepatitis B virus (HBV)-
dc.subject.localhepatitis B virus-
dc.subject.localhepatitis B Virus (HBV)-
dc.subject.localHepatitis B virus-
dc.subject.localnatively unstructured protein-
dc.subject.localNMR-
dc.subject.localnuclear magnetic resonance (Nmr)-
dc.subject.localNuclear magnetic resonance-
dc.subject.localnuclear magnetic resonance-
dc.subject.localNuclear magnetic resonance (NMR)-
dc.subject.localPreSMos (Pre-Structured Motifs)-
dc.subject.localPre-structured motif-
dc.subject.localPrestructured motif (PreSMo)-
dc.subject.localPre-structured motif (PreSMo)-
dc.subject.localPreSMo (Pre-Structured Motif)-
dc.subject.localpre-structured motif-
dc.subject.localpre-structured motifs (PreSMos)-
dc.subject.localPre-Structured Motif (PreSMo)-
dc.subject.localPreSMo-
dc.subject.localPreSMos (pre-structured motifs)-
dc.subject.localPreS1-
dc.subject.localpreS1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > 1. Journal Articles
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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