Hydroxylated hydrocinnamides as hypocholesterolemic agents

Cited 10 time in scopus
Metadata Downloads
Title
Hydroxylated hydrocinnamides as hypocholesterolemic agents
Author(s)
Sangku LeeChul Ho Lee; E Kim; S H Jung; Hyeong Kyu Lee
Bibliographic Citation
Bulletin of Korean Chemical Society, vol. 28, no. 10, pp. 1787-1791
Publication Year
2007
Abstract
Several hydroxylated cinnamic acid derivatives were prepared from the corresponding acids and amino acid residues, and their hypocholesterolemic activities were evaluated in high cholesterol-fed mice. The presence of the double bond in hydroxylated cinnamide derivatives decreases cholesterol-lowering activities and the number of free phenolic hydroxy groups affect greatly the activities. 3,4-Dihydroxy hydrocinnamides obtained from amino acid derivatives containing a hydrophobic side chain such as alanine, valine, phenylalanine, and isoleucine exhibited potent cholesterol-lowering activities.
Keyword
Amino acidCinnamic acidHydrocinnamideHypocholesterolemic activity
ISSN
0253-2964
Publisher
Wiley
DOI
http://dx.doi.org/10.5012/bkcs.2007.28.10.1787
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.