Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1

Abstract

In the course of screening for inhibitors of Staphylococcus aureus peptide deformylase, four new glycosylated macrolactin compounds, macrolactins O (1), P (2), Q (3), and R (4), along with the known macrolactins B (5) and C (6), have been isolated from the liquid cultures of Bacillus sp. AH159-1. The structures of compounds 1-4 were assigned on the basis of MS and NMR data. They inhibited S. aureus peptide deformylase and also showed antibacterial activity against Escherichia coli and Staphylococcus aureus.