Xanthones from Cudrania tricuspidata displaying potent α-glucosidase inhibition = 꾸지뽕나무로부터 강력한 알파글루코시데이스 억제제인 잔톤화합물의 개발

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Title
Xanthones from Cudrania tricuspidata displaying potent α-glucosidase inhibition = 꾸지뽕나무로부터 강력한 알파글루코시데이스 억제제인 잔톤화합물의 개발
Author(s)
E J Seo; M J Curtis-Long; B W Lee; H Y Kim; Young Bae RyuTae Sook JeongWoo Song Lee; K H Park
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 23, pp. 6421-6424
Publication Year
2007
Abstract
We have proven that xanthones 1-8 isolated from the root of C. tricuspidata possess highly potent αα-glucosidase inhibition properties. Compound 1 was identified as a new isoprenylated tetrahydroxy xanthone, 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one (1). These are the first natural xanthones documented to exhibit such inhibition. The IC50 values of compounds 1-8 inhibiting α-glucosidase activity were determined to be up to 16.2 μM. Mechanistic analysis showed the xanthones 1-8 exhibited full mixed inhibition.
Keyword
α-glucosidase inhibitioncudrania tricuspidataxanthone
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2007.10.007
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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