Antitumor activity of cytokine-induced killer cells against human lung cancer

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dc.contributor.authorHwan Mook Kim-
dc.contributor.authorJ Lim-
dc.contributor.authorSong Kyu Park-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorKiho Lee-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorKi Hoon Lee-
dc.contributor.authorM J Yun-
dc.contributor.authorK H Yang-
dc.contributor.authorG Han-
dc.contributor.authorS W Kwon-
dc.contributor.authorY Kim-
dc.contributor.authorS B Han-
dc.date.accessioned2017-04-19T09:08:21Z-
dc.date.available2017-04-19T09:08:21Z-
dc.date.issued2007-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2007.08.016ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8137-
dc.description.abstractLung cancer is the leading cause of cancer-related death among men and women in the world. Despite the aggressive treatment with surgery, radiation and chemotherapy, the long term survival for lung cancer patients remains low. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human lung cancer was evaluated in vitro and in vivo. Although CD3+CD56+ CIK cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 98% of NCI-H460 human lung cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at doses of 3 and 30 million cells per mouse inhibited 57% and 77% of NCI-H460 tumor growth in nude mouse xenograft assay, respectively. This study suggests that CD3+CD56+ CIK cells may be used as an adoptive immunotherapy for patients with lung cancer.-
dc.publisherElsevier-
dc.titleAntitumor activity of cytokine-induced killer cells against human lung cancer-
dc.title.alternativeAntitumor activity of cytokine-induced killer cells against human lung cancer-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number13-
dc.citation.endPage1807-
dc.citation.startPage1802-
dc.citation.volume7-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.affiliatedAuthorSong Kyu Park-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.affiliatedAuthorKiho Lee-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorKi Hoon Lee-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName임재승-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName이기훈-
dc.contributor.alternativeName윤미정-
dc.contributor.alternativeName양규환-
dc.contributor.alternativeName한균희-
dc.contributor.alternativeName권수우-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName한상배-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 7, no. 13, pp. 1802-1807-
dc.identifier.doi10.1016/j.intimp.2007.08.016-
dc.subject.keywordAdoptive immunotherapy-
dc.subject.keywordCytokine-induced killer cells-
dc.subject.keywordLung cancer-
dc.subject.localAdoptive immunotherapy-
dc.subject.localCytokine-induced killer cell-
dc.subject.localCytokine-induced killer cells-
dc.subject.localCytokine-induced killer(CIK) cells-
dc.subject.locallung cancer-
dc.subject.localLung Cancer-
dc.subject.localLung cancer-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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