New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus

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Title
New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus
Author(s)
In Kyoung Lee; Young Sook Kim; Yun Woo Jang; J Y Jung; Bong Sik Yun
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 24, pp. 6678-6681
Publication Year
2007
Abstract
The fruiting body of Inonotus obliquus, a medicinal mushroom called chaga, has been used as a traditional medicine for cancer treatment. Although this mushroom has been known to exhibit potent antioxidant activity, the mechanisms responsible for this activity remain unknown. In our investigation for free radical scavengers from the methanolic extract of this mushroom, inonoblins A (1), B (2), and C (3) were isolated along with the known compounds, phelligridins D (4), E (5), and G (6). Their structures were established by extensive spectroscopic analyses. These compounds exhibited significant scavenging activity against the ABTS radical cation and DPPH radical, and showed moderate activity against the superoxide radical anion.
Keyword
Free radical scavengerHispidin derivativeInonoblinsInonotus obliquusMushroom
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2007.10.072
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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