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- Title
- New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus
- Author(s)
- In Kyoung Lee; Young Sook Kim; Yun Woo Jang; J Y Jung; Bong Sik Yun
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 24, pp. 6678-6681
- Publication Year
- 2007
- Abstract
- The fruiting body of Inonotus obliquus, a medicinal mushroom called chaga, has been used as a traditional medicine for cancer treatment. Although this mushroom has been known to exhibit potent antioxidant activity, the mechanisms responsible for this activity remain unknown. In our investigation for free radical scavengers from the methanolic extract of this mushroom, inonoblins A (1), B (2), and C (3) were isolated along with the known compounds, phelligridins D (4), E (5), and G (6). Their structures were established by extensive spectroscopic analyses. These compounds exhibited significant scavenging activity against the ABTS radical cation and DPPH radical, and showed moderate activity against the superoxide radical anion.
- Keyword
- Free radical scavengerHispidin derivativeInonoblinsInonotus obliquusMushroom
- ISSN
- 0960-894X
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.bmcl.2007.10.072
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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