Cytotoxicity of triterpenes isolated from Aceriphyllum rossii

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Title
Cytotoxicity of triterpenes isolated from Aceriphyllum rossii
Author(s)
I Lee; J K Yoo; M Na; B S Min; J Lee; Bong Sik Yun; W Y Jin; H Kim; U Youn; Q C Chen; K S Song; Y H Seong; K Bae
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 55, no. 9, pp. 1376-1378
Publication Year
2007
Abstract
Bioassay-guided fractionation of a MeOH extract of the whole plant of Aceriphyllum rossii (Saxifragaceae) led to the isolation of two new triterpenes, 3 α,23-isopropylidenedioxyolean-12-en-27-oic acid (1) and 23-hydroxy-3-oxoolean-12-en-27-oic acid (2), together with six known triterpenes, 3-oxoolean-12-en-27-oic acid (3), 3 α-hydroxyolean-12-en-27- oic acid (4), β-peltoboykinolic acid (5), aceriphyllic acid A (6), oleanolic acid (7), and gypsogenic acid (8). The structures of these compounds were elucidated on the basis of physicochemical and spectroscopic analyses. These compounds were evaluated for in vitro cytotoxicity against the K562 and HL-60 cell lines. Olean-12-en-27-oic acid derivatives (1-6) exhibited considerable cytotoxicity against K562 and HL-60 cell lines with IC50 values ranging from 12.2 to 28.7 μM and from 12.1 to 25.8 μM, respectively.
Keyword
TriterpeneAceriphyllum rossiiCytotoxicitySaxifragaceae
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.55.1376
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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