Anti-obesity activity, anti-cancer activity and single oral dose toxicity of Inonotus xeranticus extracts = 기와층버섯 추출물의 항비만활성, 항암활성 및 단회경구독성시험

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorE H Kang-
dc.contributor.authorIn Kyoung Lee-
dc.contributor.authorM H Hwang-
dc.contributor.authorJ Y Choi-
dc.contributor.authorZ Q Chang-
dc.contributor.authorM H Rhee-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorC Z Jiang-
dc.contributor.authorK S Kim-
dc.contributor.authorS C Park-
dc.date.accessioned2017-04-19T09:08:27Z-
dc.date.available2017-04-19T09:08:27Z-
dc.date.issued2007-
dc.identifier.issnI000-0084-
dc.identifier.uri10.5487/TR.2007.23.3.253ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8154-
dc.description.abstractIn this study, we investigated the in vitro anti-obesity, anti-cancer activity and single oral dose toxicity of Inonotus xeranticus extracted by methanol (INXM) or ethyl acetate (INXE). In order to investigate anti-obestity effect of Inonotus xeranticus extracts, the 3T3-L1 cells were treated with these extracts at various concentrations(1, 10, 100 and 300 μg/ml). It was observed that 3T3-L1 cells treated with 100 μg/ml of Inonotus obliquus ethyl acetate extract (INOE), INXM and INXE, in the absence of differentiation cocktail (0.5 mM isobutylmethylxanthine (IBMX) 1 μM dexamethasone, 1 μg/ml insulin), differentiated at a rate of 78.5, 80.9, and 76.4% respectively. Differentiation rates of 86.6% and 83.4% were observed in 3T3-L1 cells which were treated with differentiation cocktail at 100 μg/ml of INXM and INXE, respectively. The anti-cancer effect of Inonotus xeranticus extracts was investigated using a method of sulforhodamine B in sarcoma 180 cell line. The cells were treated with these extracts (1, 10, 100 and 300 μg/ml) for 48 hours. The growth of cells which were treated with 300 μg/ml of INXM was inhibited by 80.1%. The growth of sarcoma 180 cells which were treated with 100 and 300 μg/ml of INXE was inhibited by 74.7% and 64.5%, respectively. In single oral dose toxicity study, no differences were observed between control and treated groups in clinical signs, body weight gains, and feed and water consumptions. The results indicated that Inonotus xeranticus extracts did not show any toxic effects at 2,000 mg/kg in mice, and the LD50 of these extracts was found to be higher than 2,000 mg/kg in this experiment. From the above results, Inonotus xeranticus methanol and ethyl acetate extracts might have useful clinical applications in the management of cancer and obesity and may also be useful as a medicinal food.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleAnti-obesity activity, anti-cancer activity and single oral dose toxicity of Inonotus xeranticus extracts = 기와층버섯 추출물의 항비만활성, 항암활성 및 단회경구독성시험-
dc.title.alternativeAnti-obesity activity, anti-cancer activity and single oral dose toxicity of Inonotus xeranticus extracts-
dc.typeArticle-
dc.citation.titleJournal of Toxicology and Pubic Health-
dc.citation.number3-
dc.citation.endPage261-
dc.citation.startPage253-
dc.citation.volume23-
dc.contributor.affiliatedAuthorIn Kyoung Lee-
dc.contributor.affiliatedAuthorBong Sik Yun-
dc.contributor.alternativeName강은희-
dc.contributor.alternativeName이인경-
dc.contributor.alternativeName황미현-
dc.contributor.alternativeName최재영-
dc.contributor.alternativeName창즐치앙-
dc.contributor.alternativeName이만휘-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName강성철-
dc.contributor.alternativeName김길수-
dc.contributor.alternativeName박승춘-
dc.identifier.bibliographicCitationJournal of Toxicology and Pubic Health, vol. 23, no. 3, pp. 253-261-
dc.identifier.doi10.5487/TR.2007.23.3.253-
dc.subject.keywordinonotus xeranticus-
dc.subject.keywordsingle-dose toxicity-
dc.subject.keyword3T3-L1-
dc.subject.keywordanti-cancer-
dc.subject.keywordanti-obesity-
dc.subject.localinonotus xeranticus-
dc.subject.localInonotus xeranticus-
dc.subject.localsingle-dose toxicity-
dc.subject.localSingle-dose toxicity-
dc.subject.local3T3-L1-
dc.subject.localAnti-cancer-
dc.subject.localAnticancer-
dc.subject.localanti-cancer-
dc.subject.localanticancer-
dc.subject.localAnti-Cancer-
dc.subject.localAnti-obesity-
dc.subject.localanti-obesity-
dc.subject.localantiobesity-
dc.description.journalClassN-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.