Statins and their effects on embryonic stem cells = 스타틴 그리고 배아줄기세포에서의 작용

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Title
Statins and their effects on embryonic stem cells = 스타틴 그리고 배아줄기세포에서의 작용
Author(s)
M H Lee; Y M Han; Yeesook Cho
Bibliographic Citation
Development & Reproduction, vol. 11, no. 2, pp. 59-66
Publication Year
2007
Abstract
Understanding molecular mechanisms that control embryonic stem cell (ESC) self-renewal and differentiation is important for the development of ESC-based therapies. Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), potently reduce cholesterol level. As well as inhibiting cholesterol synthesis, statins inhibit other intermediates in the mevalonate pathway such as farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), major substrates for protein isoprenylation. Studies showed that pleiotropic effects of statins beyond cholesterol lowering property arise from inhibition of protein isoprenylation that is involved in various cellular functions including proliferation and differentiation. It has been determined that statins have inhibitory effect on ESC self-renewal and stimulatory effect on ESC differentiation into adipogenic/osteogenic lineages. Importantly, statins mediate downregulation of ESC self-renewal by inhibiting RhoA-dependent signaling, independently of their choresterol-lowering properties. Understanding statin's actions on ESCs may provide important insights into the molecular mechanisms that regulate self-renewal or differentiation of ESCs.
Keyword
statinGGPPFPPisoprenylationembryonic stem cellsG-protein
ISSN
I000-0126
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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