Alteration of gene expression pattern in the mouse heart with infarction

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Title
Alteration of gene expression pattern in the mouse heart with infarction
Author(s)
Jun Kyoung Choe; Eun Kyung Kim; D Y Ryu; Young Suk Won; Og Sung Moon; Cheol-Goo Hur; Hyoung-Chin Kim; B Ahn; Ki Hoan Nam
Bibliographic Citation
Laboratory Animal Research, vol. 23, no. 3, pp. 317-320
Publication Year
2007
Abstract
Myocardial infarction (MI) is one of the leading causes of death in advanced nations. The therapeutic option is limited for chronic heart failure which is the result of MI. Recently, it has been reported that adult cardomyocytes can proliferate although the proliferating ability is quite low. To find clues for efficient induction of myocardial proliferation in heart with MI, we analyzed gene expression pattern in the heart with MI using microarray assay in mice. We found 17 and 8 genes of which the expression level increased and decreased in mouse heart with MI compared with those in normal ones, respectively. These alterations in the gene expressions reflect the heart under healing from MI. Therefore, further analysis for these genetic changes may helpful in future cell-based therapeutic application and induction of myocardial cell proliferation in patients with MI.
Keyword
myocardial infactionmicroarraymouse
ISSN
1738-6055
Publisher
Springer-BMC
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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