Alteration of gene expression pattern in the mouse heart with infarction

Abstract

Myocardial infarction (MI) is one of the leading causes of death in advanced nations. The therapeutic option is limited for chronic heart failure which is the result of MI. Recently, it has been reported that adult cardomyocytes can proliferate although the proliferating ability is quite low. To find clues for efficient induction of myocardial proliferation in heart with MI, we analyzed gene expression pattern in the heart with MI using microarray assay in mice. We found 17 and 8 genes of which the expression level increased and decreased in mouse heart with MI compared with those in normal ones, respectively. These alterations in the gene expressions reflect the heart under healing from MI. Therefore, further analysis for these genetic changes may helpful in future cell-based therapeutic application and induction of myocardial cell proliferation in patients with MI.