4-week toxicity study of concrete and Hwangto building environments in rats

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4-week toxicity study of concrete and Hwangto building environments in rats
S W Lee; H Z Hwang; Hyoung-Chin Kim; S C Park; J M Son; Y S Yang; T H Ahn; S H Kim; J C Kim
Bibliographic Citation
Laboratory Animal Science, vol. 22, no. 4, pp. 373-381
Publication Year
This study was carried out to examine the potential subacute toxicity of 4-week exposure of rats to concrete and hwangto building environments. Polycarbonate was used as a comparison. Groups of 10 male rats were exposed to polycarbonate, concrete, or hwangto cages for a 4-week period (23 November-20 December) under the natural environments of winter. During the study period, the clinical signs, mortality, skin temperature, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, organ weights and histopathology were examined. The concentration of total volatile organic compounds (VOCs), temperature and relative humidity in the each cages were also measured. The temperature, relative humidity, and the concentration of VOCs in the cages were similar in all groups. However, significant differences in several health parameters were detected among the groups. In the concrete group, there was an increase in the clinical signs, a reduction in the body weight gain, food intake and liver weight, an increase in the lung weight, and an increase in the histopathological alterations in the lung and thymus. Infrared thermal analysis showed that the skin temperature of the rats in the concrete group was lower than in the polycarbonate group. However, in the hwangto group, there was a decrease in the clinical signs and an increase in the body weight, food intake, and the weights of the heart, lung, spleen and epididymides. Overall, the 4-week exposure of the rats to the concrete building environment had adverse effects on the clinical signs, skin temperature, body weight, and some organs in the winter. On the other hand, the exposure of hwangto building environment did not have any exposurerelated adverse effects on the general health parameters and skin temperature in rats.
housing environmentbuilding materialsconcretehwangtosubacute toxicityrats
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Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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