Two step carcinogen screening model using neonatal FVB/NJ mouse

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dc.contributor.authorYoung Suk Won-
dc.contributor.authorHyo Jung Kwon-
dc.contributor.authorY K Choi-
dc.contributor.authorH J Park-
dc.contributor.authorE S Jeong-
dc.contributor.authorBon Chul Koo-
dc.contributor.authorOg Sung Moon-
dc.contributor.authorKi Hoan Nam-
dc.contributor.authorHyoung-Chin Kim-
dc.date.accessioned2017-04-19T09:08:30Z-
dc.date.available2017-04-19T09:08:30Z-
dc.date.issued2007-
dc.identifier.issn1738-6055-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8174-
dc.description.abstractA long-term carcinogenicity study is required to assess the safety of new drug candidates. This classical toxicological method has been using rats and mice as animal systems. The International Conference on Harmonization (ICH) of technical requirements of pharmaceuticals for human use have recommended one long-term rodent carcinogenicity test using rat and one other supplementary mouse study such as an initiation-promotion model, a transgenic model or a neonatal model. This study was carried out to develop an initiation-promotion liver carcinogenicity model using a mouse. Twelve-day old FVB/NJ mice were intraperitoneally injected with diethyl nitrosamine (DEN) as an initiator and orally administered with 2-acetlyaminofluorene (2-AAF) as a promoter. And D-galactosamine (DGA) was injected as a stimulator for tumorigenic progress. Basophilic foci in the liver were observed 16 weeks after initiation. The incidence of hepatocellular adenoma was increased in animals 2-AAF-treated at 20 and 26 weeks after initiation. The tumor incidence in 2-AAF-treated animals were significantly higher than with the untreatment and initiator treatment control groups. Hepatocellular carcinoma (HCC) was found in some cases. These results suggest that two-step neonatal FVB/NJ mouse model could be useful for carcinogenic assay of new drug candidates.-
dc.publisherSpringer-BMC-
dc.titleTwo step carcinogen screening model using neonatal FVB/NJ mouse-
dc.title.alternativeTwo step carcinogen screening model using neonatal FVB/NJ mouse-
dc.typeArticle-
dc.citation.titleLaboratory Animal Research-
dc.citation.number3-
dc.citation.endPage243-
dc.citation.startPage239-
dc.citation.volume23-
dc.contributor.affiliatedAuthorYoung Suk Won-
dc.contributor.affiliatedAuthorHyo Jung Kwon-
dc.contributor.affiliatedAuthorBon Chul Koo-
dc.contributor.affiliatedAuthorOg Sung Moon-
dc.contributor.affiliatedAuthorKi Hoan Nam-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.alternativeName원영석-
dc.contributor.alternativeName권효정-
dc.contributor.alternativeName최양규-
dc.contributor.alternativeName박현지-
dc.contributor.alternativeName정의석-
dc.contributor.alternativeName구본철-
dc.contributor.alternativeName문옥성-
dc.contributor.alternativeName남기환-
dc.contributor.alternativeName김형진-
dc.identifier.bibliographicCitationLaboratory Animal Research, vol. 23, no. 3, pp. 239-243-
dc.subject.keywordFVB/NJ-
dc.subject.keywordcarcinogenesis-
dc.subject.keywordhepatocellular adenoma-
dc.subject.keyword2-acetlyaminofluorene (2-AAF)-
dc.subject.localFVB/NJ-
dc.subject.localcarcinogenesis-
dc.subject.localCarcinogenesis-
dc.subject.localHepatocellular adenoma-
dc.subject.localhepatocellular adenoma-
dc.subject.local2-acetylaminofluorene (2-AAF)-
dc.subject.local2-acetlyaminofluorene (2-AAF)-
dc.subject.local2-acetylaminofluorene-
dc.subject.local2-Acetylaminofluorene-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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