Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma

Cited 39 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorG R Yu-
dc.contributor.authorS H Kim-
dc.contributor.authorS H Park-
dc.contributor.authorX D Cui-
dc.contributor.authorD Y Xu-
dc.contributor.authorH C Yu-
dc.contributor.authorB H Cho-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorS S Kim-
dc.contributor.authorS B Kim-
dc.contributor.authorIn-Sun Chu-
dc.contributor.authorD G Kim-
dc.date.accessioned2017-04-19T09:08:40Z-
dc.date.available2017-04-19T09:08:40Z-
dc.date.issued2007-
dc.identifier.issnI000-0028-
dc.identifier.uri10.1038/emm.2007.70ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8187-
dc.description.abstractThe aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tumor tissues (NT) from 40 patients were analyzed. of total 217 genes, 72 were expressed preferentially in HCC tissues. Among 186 differentially regulated genes, there were molecular chaperone and tumor suppressor gene clusters in the Edmondson grades I and II (GI/II) subclass compared with the liver cirrhosis (LC) subclass. The Edmondson grades III and IV (GIII/IV) subclass with a poor survival (P = 0.0133) contained 122 differentially regulated genes with a cluster containing various metastasis- and invasion-related genes compared with the GI/II subclass. Immunohistochemical analysis revealed that ANXA2, one of the 72 genes preferentially expressed in HCC, was over-expressed in the sinusoidal endothelium and in malignant hepatocytes in HCC. The genes identified in the HCC subclasses will be useful molecular markers for the genesis and progression of HCC. In addition, ANXA2 might be a novel marker for tumor angiogenesis in HCC.-
dc.publisherSpringer-Nature Pub Group-
dc.titleIdentification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma-
dc.title.alternativeIdentification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number5-
dc.citation.endPage652-
dc.citation.startPage641-
dc.citation.volume39-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.affiliatedAuthorS B Kim-
dc.contributor.affiliatedAuthorIn-Sun Chu-
dc.contributor.alternativeName유경란-
dc.contributor.alternativeName김성현-
dc.contributor.alternativeName박선화-
dc.contributor.alternativeNameCui-
dc.contributor.alternativeNameXu-
dc.contributor.alternativeName유희철-
dc.contributor.alternativeName조벽환-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName김상수-
dc.contributor.alternativeName김상배-
dc.contributor.alternativeName추인선-
dc.contributor.alternativeName김대곤-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 39, no. 5, pp. 641-652-
dc.identifier.doi10.1038/emm.2007.70-
dc.subject.keywordAngiogenesis-
dc.subject.keywordCarcinoma, hepatocellular-
dc.subject.keywordCell differentiation-
dc.subject.keywordGene expression profiling-
dc.subject.keywordTumor markers, biological-
dc.subject.localAngiogenesis-
dc.subject.localangiogenesis-
dc.subject.localCarcinoma, hepatocellular-
dc.subject.localcarcinoma, hepatocellular-
dc.subject.localcell differentiation-
dc.subject.localCell differentiation-
dc.subject.localGene expression profiling.-
dc.subject.localGene expression profiling-
dc.subject.localgene expression profiling-
dc.subject.localTumor markers, biological-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.