Inhibition of human ovarian tumor growth by cytokine-induced killer cells

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Inhibition of human ovarian tumor growth by cytokine-induced killer cells
Hwan Mook Kim; Jong Soon Kang; J Lim; Song Kyu Park; Kiho Lee; Yeo Dae YoonChang Woo LeeKi Hoon Lee; G Han; K H Yang; Y J Kim; Y Kim; S B Han
Bibliographic Citation
Archives of Pharmacal Research, vol. 30, no. 11, pp. 1464-1470
Publication Year
Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo. Although CD3+CD56 + cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer.
Cytokine-induced killer cellsOvarian cancerAdoptive immunotherapy
Pharmaceutical Soc Korea
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Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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