Inhibition of human ovarian tumor growth by cytokine-induced killer cells

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dc.contributor.authorHwan Mook Kim-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorJ Lim-
dc.contributor.authorSong Kyu Park-
dc.contributor.authorKiho Lee-
dc.contributor.authorYeo Dae Yoon-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorKi Hoon Lee-
dc.contributor.authorG Han-
dc.contributor.authorK H Yang-
dc.contributor.authorY J Kim-
dc.contributor.authorY Kim-
dc.contributor.authorS B Han-
dc.date.accessioned2017-04-19T09:08:42Z-
dc.date.available2017-04-19T09:08:42Z-
dc.date.issued2007-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/BF02977372ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8201-
dc.description.abstractDespite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo. Although CD3+CD56 + cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer.-
dc.publisherPharmaceutical Soc Korea-
dc.titleInhibition of human ovarian tumor growth by cytokine-induced killer cells-
dc.title.alternativeInhibition of human ovarian tumor growth by cytokine-induced killer cells-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number11-
dc.citation.endPage1470-
dc.citation.startPage1464-
dc.citation.volume30-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.affiliatedAuthorSong Kyu Park-
dc.contributor.affiliatedAuthorKiho Lee-
dc.contributor.affiliatedAuthorYeo Dae Yoon-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorKi Hoon Lee-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName임재승-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName윤여대-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName이기훈-
dc.contributor.alternativeName한균희-
dc.contributor.alternativeName양규환-
dc.contributor.alternativeName김연진-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName한상배-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 30, no. 11, pp. 1464-1470-
dc.identifier.doi10.1007/BF02977372-
dc.subject.keywordAdoptive immunotherapy-
dc.subject.keywordCytokine-induced killer cells-
dc.subject.keywordOvarian cancer-
dc.subject.localAdoptive immunotherapy-
dc.subject.localCytokine-induced killer cell-
dc.subject.localCytokine-induced killer cells-
dc.subject.localCytokine-induced killer(CIK) cells-
dc.subject.localovarian cancer-
dc.subject.localOvarian cancer-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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