DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwan Mook Kim | - |
dc.contributor.author | Jong Soon Kang | - |
dc.contributor.author | J Lim | - |
dc.contributor.author | Song Kyu Park | - |
dc.contributor.author | Kiho Lee | - |
dc.contributor.author | Yeo Dae Yoon | - |
dc.contributor.author | Chang Woo Lee | - |
dc.contributor.author | Ki Hoon Lee | - |
dc.contributor.author | G Han | - |
dc.contributor.author | K H Yang | - |
dc.contributor.author | Y J Kim | - |
dc.contributor.author | Y Kim | - |
dc.contributor.author | S B Han | - |
dc.date.accessioned | 2017-04-19T09:08:42Z | - |
dc.date.available | 2017-04-19T09:08:42Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | 10.1007/BF02977372 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8201 | - |
dc.description.abstract | Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo. Although CD3+CD56 + cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer. | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Inhibition of human ovarian tumor growth by cytokine-induced killer cells | - |
dc.title.alternative | Inhibition of human ovarian tumor growth by cytokine-induced killer cells | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 11 | - |
dc.citation.endPage | 1470 | - |
dc.citation.startPage | 1464 | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
dc.contributor.affiliatedAuthor | Jong Soon Kang | - |
dc.contributor.affiliatedAuthor | Song Kyu Park | - |
dc.contributor.affiliatedAuthor | Kiho Lee | - |
dc.contributor.affiliatedAuthor | Yeo Dae Yoon | - |
dc.contributor.affiliatedAuthor | Chang Woo Lee | - |
dc.contributor.affiliatedAuthor | Ki Hoon Lee | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.contributor.alternativeName | 강종순 | - |
dc.contributor.alternativeName | 임재승 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.contributor.alternativeName | 이기호 | - |
dc.contributor.alternativeName | 윤여대 | - |
dc.contributor.alternativeName | 이창우 | - |
dc.contributor.alternativeName | 이기훈 | - |
dc.contributor.alternativeName | 한균희 | - |
dc.contributor.alternativeName | 양규환 | - |
dc.contributor.alternativeName | 김연진 | - |
dc.contributor.alternativeName | 김영수 | - |
dc.contributor.alternativeName | 한상배 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 30, no. 11, pp. 1464-1470 | - |
dc.identifier.doi | 10.1007/BF02977372 | - |
dc.subject.keyword | Adoptive immunotherapy | - |
dc.subject.keyword | Cytokine-induced killer cells | - |
dc.subject.keyword | Ovarian cancer | - |
dc.subject.local | Adoptive immunotherapy | - |
dc.subject.local | Cytokine-induced killer cell | - |
dc.subject.local | Cytokine-induced killer cells | - |
dc.subject.local | Cytokine-induced killer(CIK) cells | - |
dc.subject.local | ovarian cancer | - |
dc.subject.local | Ovarian cancer | - |
dc.description.journalClass | Y | - |
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