Antioxidant and antiatherogenic activity of cis-hinokiresinol from Trapa pseudoincisa

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Title
Antioxidant and antiatherogenic activity of cis-hinokiresinol from Trapa pseudoincisa
Author(s)
M C Song; H J Yang; M H Bang; D K Kim; Tae Sook JeongJong Pyung Kim; N I Baek
Bibliographic Citation
Archives of Pharmacal Research, vol. 30, no. 11, pp. 1392-1397
Publication Year
2007
Abstract
cis-Hinokiresinol, also known as (+)-nyasol, was isolated for the first time from an aquatic herbaceous plant, Trapa pseudoincisa NAKAI, via silica gel and octadecyl silica gel column chromatographies. The chemical structure was determined via analyses of the spectroscopic data, including NMR, MS and IR. cis-Hinokiresinol was also found to exhibit antioxidant and antiatherogenic activities. The IC50 values for the scavenging activities of cis-hinokiresinol on ABTS cation and superoxide anion radicals were 45.6 and 40.5 μM, respectively. The IC50 values for the inhibitory effects on Lp-PLA2, hACAT1, hACAT2 and LDL-oxidation were 284.7, 280.6, 398.9 and 5.6 μM, respectively.
Keyword
ABTScis-HinokiresinolhACATLDL-oxidationLp-PLA2SuperoxideTrapa pseudoincisa
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977362
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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