Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites
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- Title
- Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites
- Author(s)
- Kyeong Lee; J S Ryu; Y Jin; Won Cheol Kim; N Kaur; Sang Jeon Chung; Y J Jeon; J T Park; J S Bang; H S Lee; T Y Kim; Jung Joon Lee; Young-Soo Hong
- Bibliographic Citation
- Organic & Biomolecular Chemistry, vol. 6, no. 2, pp. 340-348
- Publication Year
- 2008
- Abstract
- A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.
- ISSN
- 1477-0520
- Publisher
- Royal Soc Chem
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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