Functional proteomic study reveals that N-acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on TIMP-1

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dc.contributor.authorYong Sam Kim-
dc.contributor.authorS Y Hwang-
dc.contributor.authorHye Yeon Kang-
dc.contributor.authorH Sohn-
dc.contributor.authorS Oh-
dc.contributor.authorJ Y Kim-
dc.contributor.authorJ S Yoo-
dc.contributor.authorY H Kim-
dc.contributor.authorC H Kim-
dc.contributor.authorJae Heung Jeon-
dc.contributor.authorJung Mi Lee-
dc.contributor.authorHyun Ah Kang-
dc.contributor.authorE Miyoshi-
dc.contributor.authorN Taniguchi-
dc.contributor.authorHyang Sook Yoo-
dc.contributor.authorJeong Heon Ko-
dc.date.accessioned2017-04-19T09:08:49Z-
dc.date.available2017-04-19T09:08:49Z-
dc.date.issued2008-
dc.identifier.issn15359476-
dc.identifier.uri10.1074/mcp.M700084-MCP200ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8238-
dc.description.abstractN-Acetylglucosaminyltransferase-V (GnT-V) has been reported to be up-regulated in invasive/metastatic cancer cells, but a comprehensive understanding of how the transferase correlates with the invasive/ metastatic potential is not currently available. Through a glycomics approach, we identified 30 proteins, including tissue inhibitor of metalloproteinase-1 (TIMP-1), as a target protein for GnT-V in human colon cancer cell WiDr. TIMP-1 was aberrantly glycosylated as characterized by the addition of β1,6-N-acetylglucosamine, polylactosaminylation, and sialylation in GnT-V-overexpressing WiDr cells. Compared with normal TIMP-1, the aberrantly glycosylated TIMP-1 showed the weaker inhibition on both matrix metalloproteinase (MMP)-2 and MMP-9, and this aberrancy was closely associated with cancer cell invasion and metastasis in vivo as well as in vitro. Integrated data, both of TIMP-1 expression level and aberrant glycosylation, could provide important information to aid to improve the clinical outcome of colon cancer patients.-
dc.publisherAmer Soc Biochemistry Molecular Biology Inc-
dc.titleFunctional proteomic study reveals that N-acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on TIMP-1-
dc.title.alternativeFunctional proteomic study reveals that N-acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on TIMP-1-
dc.typeArticle-
dc.citation.titleMolecular & Cellular Proteomics-
dc.citation.number1-
dc.citation.endPage14-
dc.citation.startPage1-
dc.citation.volume7-
dc.contributor.affiliatedAuthorYong Sam Kim-
dc.contributor.affiliatedAuthorJae Heung Jeon-
dc.contributor.affiliatedAuthorJeong Heon Ko-
dc.contributor.alternativeName김용삼-
dc.contributor.alternativeName황수영-
dc.contributor.alternativeName강혜연-
dc.contributor.alternativeName손호성-
dc.contributor.alternativeName오세정-
dc.contributor.alternativeName김진영-
dc.contributor.alternativeName유종신-
dc.contributor.alternativeName김영환-
dc.contributor.alternativeName김철호-
dc.contributor.alternativeName전재흥-
dc.contributor.alternativeName이정미-
dc.contributor.alternativeName강현아-
dc.contributor.alternativeNameMiyoshi-
dc.contributor.alternativeNameTaniguchi-
dc.contributor.alternativeName유향숙-
dc.contributor.alternativeName고정헌-
dc.identifier.bibliographicCitationMolecular & Cellular Proteomics, vol. 7, no. 1, pp. 1-14-
dc.identifier.doi10.1074/mcp.M700084-MCP200-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Division of Biomaterials Research > Plant Systems Engineering Research > 1. Journal Articles
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