Hyaluronic acid induces transglutaminase II to enhance cell motility; role of Rac1 and FAK in the induction of transglutaminase II

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dc.contributor.authorY Kim-
dc.contributor.authorYoung Woo Park-
dc.contributor.authorY S Lee-
dc.contributor.authorD Jeong-
dc.date.accessioned2017-04-19T09:08:49Z-
dc.date.available2017-04-19T09:08:49Z-
dc.date.issued2008-
dc.identifier.issn01415492-
dc.identifier.uri10.1007/s10529-007-9496-1ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8241-
dc.description.abstractThe role of transglutaminase II (TGase II) in hyaluronic acid (HA)-promoted melanoma cell motility was investigated. HA induced the expression of TGase II via the nuclear factor κB (NF-kB) in melanoma cells. HA increased the Rac1 activity and phosphorylation of focal adhesion kinase (FAK). Transfection by lipofectamine of dominant-negative Rac1, and FAK-related non-kinase (FRNK), an endogenous inhibitor of FAK, suppressed the induction of TGase II. This suggests that Rac1 and FAK mediate induction of TGase II by HA. HA-promoted melanoma cell motility was inhibited by cystamine, an inhibitor of TGase II, and overexpression of TGase II enhanced melanoma cell motility through reactive oxygen species. Taken together, HA promotes melanoma cell motility through activation of Rac1, FAK, and induction of TGase II.-
dc.publisherSpringer-
dc.titleHyaluronic acid induces transglutaminase II to enhance cell motility; role of Rac1 and FAK in the induction of transglutaminase II-
dc.title.alternativeHyaluronic acid induces transglutaminase II to enhance cell motility; role of Rac1 and FAK in the induction of transglutaminase II-
dc.typeArticle-
dc.citation.titleBiotechnology Letters-
dc.citation.number1-
dc.citation.endPage39-
dc.citation.startPage31-
dc.citation.volume30-
dc.contributor.alternativeName김영미-
dc.contributor.alternativeName박영우-
dc.contributor.alternativeName이윤실-
dc.contributor.alternativeName정두일-
dc.identifier.bibliographicCitationBiotechnology Letters, vol. 30, no. 1, pp. 31-39-
dc.identifier.doi10.1007/s10529-007-9496-1-
dc.subject.keywordFocal adhesion kinase-
dc.subject.keywordHyaluronic acid-
dc.subject.keywordMotility-
dc.subject.keywordRac1-
dc.subject.keywordTransglutaminase II-
dc.subject.localFocal adhesion kinase-
dc.subject.localHyaluronic acid-
dc.subject.localMotility-
dc.subject.localRac1-
dc.subject.localTransglutaminase II-
dc.description.journalClassY-
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