Prenylated flavonoids with PTP1B inhibitory activity from the root bark of Erythrina mildbraedii

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Title
Prenylated flavonoids with PTP1B inhibitory activity from the root bark of Erythrina mildbraedii
Author(s)
JunPil Jang; Min Kyun Na; P T Thuong; D Njamen; J T Mbafor; Z T Fomum; E R Woo; W K Oh
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 56, no. 1, pp. 85-88
Publication Year
2008
Abstract
Phytochemical study on an EtOAc-soluble extract of the root bark of Erythrina mildbraedii resulted in the isolation of six prenylated flavonoids 1-6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4′-O-methyl ether (1), 2′,7-dihydroxy-4′-methoxy-5′-(3-methylbut-2-enyl)isoflavone (2), and (3R)-2′,7-dihydroxy-3′-(3-methylbut-2-enyl)-2?, 2?-dimethylpyrano[5?,6?: 4′,5′]isoflavan (3), along with three known compounds erythrinin B (4), abyssinin II (5), and parvisoflavone B (6). All the isolates, except for compound 4, inhibited PTP1B activity in vitro with IC50 values ranging from 5.3 to 42.6 μM. This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.
Keyword
Erythrina mildbraediiLeguminosaePrenyl flavonoidProtein tyrosine phosphatase 1B inhibitor
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.56.85
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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