Overexpression of Shinorhizobium meliloti hemoprotein in Streptomyces lividans to enhance secondary metabolite production

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dc.contributor.authorY J Kim-
dc.contributor.authorS O Sa-
dc.contributor.authorY K Chang-
dc.contributor.authorS K Hong-
dc.contributor.authorYoung-Soo Hong-
dc.date.accessioned2017-04-19T09:08:53Z-
dc.date.available2017-04-19T09:08:53Z-
dc.date.issued2007-
dc.identifier.issn1017-7825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8252-
dc.description.abstractIt was found that Shinorhizobium meliloti hemoprotein (SM) was more effective than Vitreoscilla hemoglobin (Vhb) in promoting secondary metabolites production when overexpressed in Streptomyces lividans TK24. The transformant with sm (sm-transformant) produced 2.7-times and 3-times larger amounts of actinorhodin than the vhb-transformant in solid culture and flask culture, respectively. In both solid and flask cultures, a larger amount of undecylprodigiocin was produced by the sm-transformant. It is considered that the overexpression of SM especially has activated the pentose phosphate pathway through oxidative stress, as evidenced by an increased NADPH production observed, and that it has promoted secondary metabolites biosynthesis.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleOverexpression of Shinorhizobium meliloti hemoprotein in Streptomyces lividans to enhance secondary metabolite production-
dc.title.alternativeOverexpression of Shinorhizpbium meliloti hemoprotein in Streptomyces lividans to enhance secondary metabolite production-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number12-
dc.citation.endPage2070-
dc.citation.startPage2066-
dc.citation.volume17-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.alternativeName김윤정-
dc.contributor.alternativeName사순옥-
dc.contributor.alternativeName장용근-
dc.contributor.alternativeName홍순광-
dc.contributor.alternativeName홍영수-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 17, no. 12, pp. 2066-2070-
dc.subject.keywordbacterial hemoproteins-
dc.subject.keywordS. lividans-
dc.subject.keywordsecondary metabolites production-
dc.subject.localbacterial hemoproteins-
dc.subject.localS. lividans-
dc.subject.localsecondary metabolites production-
dc.subject.localsecondary metabolite production-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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