Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds

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dc.contributor.authorH S Kwon-
dc.contributor.authorMin Jung Kim-
dc.contributor.authorHyung Jae Jung-
dc.contributor.authorM S Yang-
dc.contributor.authorK H Park-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorWoo Song Lee-
dc.date.accessioned2017-04-19T09:08:54Z-
dc.date.available2017-04-19T09:08:54Z-
dc.date.issued2008-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2007.10.098ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8258-
dc.description.abstractSix diarylbutane lignans 1-5 and one aryltetralin lignan 6 were isolated from the methanol (95%) extracts of Myristica fragrans seeds and then 7-methyl ether diarylbutane lignan 4 has proven to be new a compound. Their compounds 1-7 were evaluated for LDL-antioxidant activity to identify the most potent LDL-antioxidant 3 with an IC50 value of 2.6 μM in TBARS assay. Due to its potency, compound 3 was tested for complementary in vitro investigations, such as lag time (140 min at 1.0 μM), relative electrophoretic mobility (REM) of ox-LDL (inhibition of 80% at 20 μM and 72% at 10 μM), and fragmentation of apoB-100 (inhibition of 93% at 20 μM) on copper-mediated LDL oxidation. In macrophage-mediated LDL oxidation, the TBARS formation was also inhibited by compound 3.-
dc.publisherElsevier-
dc.titleLow-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds-
dc.title.alternativeLow-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number1-
dc.citation.endPage198-
dc.citation.startPage194-
dc.citation.volume18-
dc.contributor.affiliatedAuthorHyung Jae Jung-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName권현숙-
dc.contributor.alternativeName김민정-
dc.contributor.alternativeName정형재-
dc.contributor.alternativeName양민석-
dc.contributor.alternativeName박기훈-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이우송-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 18, no. 1, pp. 194-198-
dc.identifier.doi10.1016/j.bmcl.2007.10.098-
dc.subject.keywordLDL-antioxidant-
dc.subject.keywordLignan-
dc.subject.keywordMyristica fragrans-
dc.subject.localLDL-antioxidant-
dc.subject.locallignan-
dc.subject.localLignans-
dc.subject.localLignan-
dc.subject.locallignans-
dc.subject.localMyristica fragrans-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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