DC Field | Value | Language |
---|---|---|
dc.contributor.author | H S Kwon | - |
dc.contributor.author | Min Jung Kim | - |
dc.contributor.author | Hyung Jae Jung | - |
dc.contributor.author | M S Yang | - |
dc.contributor.author | K H Park | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | Woo Song Lee | - |
dc.date.accessioned | 2017-04-19T09:08:54Z | - |
dc.date.available | 2017-04-19T09:08:54Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | 10.1016/j.bmcl.2007.10.098 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8258 | - |
dc.description.abstract | Six diarylbutane lignans 1-5 and one aryltetralin lignan 6 were isolated from the methanol (95%) extracts of Myristica fragrans seeds and then 7-methyl ether diarylbutane lignan 4 has proven to be new a compound. Their compounds 1-7 were evaluated for LDL-antioxidant activity to identify the most potent LDL-antioxidant 3 with an IC50 value of 2.6 μM in TBARS assay. Due to its potency, compound 3 was tested for complementary in vitro investigations, such as lag time (140 min at 1.0 μM), relative electrophoretic mobility (REM) of ox-LDL (inhibition of 80% at 20 μM and 72% at 10 μM), and fragmentation of apoB-100 (inhibition of 93% at 20 μM) on copper-mediated LDL oxidation. In macrophage-mediated LDL oxidation, the TBARS formation was also inhibited by compound 3. | - |
dc.publisher | Elsevier | - |
dc.title | Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds | - |
dc.title.alternative | Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 198 | - |
dc.citation.startPage | 194 | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Hyung Jae Jung | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.alternativeName | 권현숙 | - |
dc.contributor.alternativeName | 김민정 | - |
dc.contributor.alternativeName | 정형재 | - |
dc.contributor.alternativeName | 양민석 | - |
dc.contributor.alternativeName | 박기훈 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 1, pp. 194-198 | - |
dc.identifier.doi | 10.1016/j.bmcl.2007.10.098 | - |
dc.subject.keyword | LDL-antioxidant | - |
dc.subject.keyword | Lignan | - |
dc.subject.keyword | Myristica fragrans | - |
dc.subject.local | LDL-antioxidant | - |
dc.subject.local | lignan | - |
dc.subject.local | Lignans | - |
dc.subject.local | Lignan | - |
dc.subject.local | lignans | - |
dc.subject.local | Myristica fragrans | - |
dc.description.journalClass | Y | - |
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