Detection of unusual rotavirus genotypes G8P[8] and G12P[6] in South Korea

Cited 47 time in scopus
Metadata Downloads
Title
Detection of unusual rotavirus genotypes G8P[8] and G12P[6] in South Korea
Author(s)
V P Le; J Y Kim; S L Cho; S W Nam; I Lim; H J Lee; K Kim; S I Chung; W Song; K M Lee; Moon Soo RheeJung-Sook Lee; W Kim
Bibliographic Citation
Journal of Medical Virology, vol. 80, no. 1, pp. 175-182
Publication Year
2008
Abstract
Five hundred four fecal specimens, collected between 2004 and 2006 from young children with acute diarrhea, were screened for rotavirus by ELISA with VP6-specific antibody. of these samples, 394 (78.2%) were confirmed as group A rotavirus and they underwent G- and P typing using a combination of ELISA, RT-PCR, and sequence analysis methods. The dominant circulating G serotype was G1 (35.6%) followed by G3 (26.4%), G4 (14.7%), and G2 (11.9%). There was a low prevalence of G9 (1.0%) and of unusual G type rotavirus, in particular, G12 (0.5%) and G8 (0.3%). of the P genotype rotavirus in circulation, P[8] (53.0%) was most common followed by P[6] (15.5%), P[4] (15.2%), and P[9] (2.3%). Determination of G- and P type combinations revealed that G1P[8] strains were most prevalent (25.4%), amid G3P[8] (16.8%), G2P[4] (6.3%), and G4P[6] (6.1%) strains. Unusual or rare combinations such as G2P[6], G2P[8], G3P[4], G2P[9], G1P[9], G3P[9], G12P[6], G1P[4], G3P[6], and G8P[8] were also found. Owing to the recent emergence of G8 and G12 rotavirus, the findings from this study are important since they provide new information concerning the local and global spread of rotavirus genotypes.
Keyword
DiarrheaELISAG typeP typeRT-PCR
ISSN
0146-6615
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/jmv.21044
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.