Clusterin, a novel modulator of TGF-β signaling, is involved in Smad2/3 stability

Cited 44 time in scopus
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Title
Clusterin, a novel modulator of TGF-β signaling, is involved in Smad2/3 stability
Author(s)
K B Lee; J H Jeon; In Pyo Choi; O Y Kwon; Kweon Yu; K H You
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 366, no. 4, pp. 905-909
Publication Year
2008
Abstract
Clusterin (CLU) is known as a multifunctional protein involved in a variety of physiological processes including lipid transport, epithelial cell differentiation, tumorigenesis, and apoptosis. It is known that CLU interacts with TGF-β type ll receptor (TβRll). However, the relationship of CLU and TGF-β signaling is unclear. Here we present that CLU is a novel modulator of TGF-β signaling by regulating Smad2/3 proteins. Overexpression of CLU enhanced TGF-β-induced transcriptional activity and increased the amount of Smad2/3 proteins, while CLU siRNA repressed TGF-β-induced transcriptional activity and decreased the amount of Smad2/3 proteins in Hep3B cells. We also found that CLU was involved in Smad2/3 stability at the protein level. These findings suggest that CLU regulates TGF-β signaling pathway by modulating the stability of Smad2/3 proteins.
Keyword
ClusterinSmad2Smad3TGF-β
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2007.12.033
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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