Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice = C57BL/KsJ-db/db마우스에서 글루코오스와 지질대사에 있어서 순무 주정추출물의 효과

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dc.contributor.authorU J Jung-
dc.contributor.authorN I Baek-
dc.contributor.authorH G Chung-
dc.contributor.authorM H Bang-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorK T Lee-
dc.contributor.authorY J Kang-
dc.contributor.authorM K Lee-
dc.contributor.authorH J Kim-
dc.contributor.authorJ Yeo-
dc.contributor.authorM S Choi-
dc.date.accessioned2017-04-19T09:08:58Z-
dc.date.available2017-04-19T09:08:58Z-
dc.date.issued2008-
dc.identifier.issn0261-5614-
dc.identifier.uri10.1016/j.clnu.2007.09.009ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8284-
dc.description.abstractBackground & aims: The antidiabetic efficacy of turnip (Brassica rapa) roots ethanol extract (TE) was investigated in type 2 diabetic animals. Methods: C57BL/KsJ-db/db (db/db) mice and db/+ mice were used and the db/db mice were divided into control, TE (0.26g/100 g diet) and rosiglitazone (RG, 0.005 g/100 g diet) groups. Results: Despite hyperinsulinemia, the glucokinase activity was lower in the liver of the db/db mice than the db/+ mice, while the glucose-6-phosphatase activity was higher. TE and RG improved the glucose and insulin tolerance and lowered the blood glycosylated hemoglobin, plasma insulin, C-peptide and glucagon levels as well as reversed these hepatic glucose regulating enzyme activities in db/db mice. TE also increased the insulin/glucagon ratio and hepatic glycogen content. The plasma free fatty acid and plasma and hepatic cholesterol and triglyceride levels were higher in the db/db mice than db/+ mice. Interestingly, TE and RG lowered these plasma and hepatic lipids, and simultaneously reduced the hepatic phosphatidate phosphohydrolase, HMG-CoA reductase, ACAT, β-oxidation and carnitine palmitoyl transferase activities. Furthermore, TE lowered the hepatic fatty acid synthase activity, hepatic lipid droplets accumulation, and adipose tissue weight and size. Conclusions: We suggest TE may exert an antidiabetic effect in type 2 diabetic mice by enhancing the glucose and lipid metabolism.-
dc.publisherElsevier-
dc.titleEffects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice = C57BL/KsJ-db/db마우스에서 글루코오스와 지질대사에 있어서 순무 주정추출물의 효과-
dc.title.alternativeEffects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice-
dc.typeArticle-
dc.citation.titleClinical Nutrition-
dc.citation.number1-
dc.citation.endPage167-
dc.citation.startPage158-
dc.citation.volume27-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName정은주-
dc.contributor.alternativeName백남인-
dc.contributor.alternativeName정해건-
dc.contributor.alternativeName방면호-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이경태-
dc.contributor.alternativeName강영진-
dc.contributor.alternativeName이미경-
dc.contributor.alternativeName김혜진-
dc.contributor.alternativeName여지영-
dc.contributor.alternativeName최명숙-
dc.identifier.bibliographicCitationClinical Nutrition, vol. 27, no. 1, pp. 158-167-
dc.identifier.doi10.1016/j.clnu.2007.09.009-
dc.subject.keywordBrassica rapa-
dc.subject.keywordGlucose regulating enzymes-
dc.subject.keywordGlucose tolerance-
dc.subject.keywordInsulin resistance-
dc.subject.keywordLipid regulating enzymes-
dc.subject.keywordType 2 diabetes-
dc.subject.localbrassica rapa-
dc.subject.localBrassica rapa-
dc.subject.localglucose regulating enzymes-
dc.subject.localGlucose regulating enzymes-
dc.subject.localGlucose tolerance-
dc.subject.localglucose tolerance-
dc.subject.localInsulin resistance-
dc.subject.localinsulin resistance-
dc.subject.localLipid regulating enzymes-
dc.subject.localType 2 diabetes-
dc.subject.localType 2 Diabetes-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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