DC Field | Value | Language |
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dc.contributor.author | U J Jung | - |
dc.contributor.author | N I Baek | - |
dc.contributor.author | H G Chung | - |
dc.contributor.author | M H Bang | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | K T Lee | - |
dc.contributor.author | Y J Kang | - |
dc.contributor.author | M K Lee | - |
dc.contributor.author | H J Kim | - |
dc.contributor.author | J Yeo | - |
dc.contributor.author | M S Choi | - |
dc.date.accessioned | 2017-04-19T09:08:58Z | - |
dc.date.available | 2017-04-19T09:08:58Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0261-5614 | - |
dc.identifier.uri | 10.1016/j.clnu.2007.09.009 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8284 | - |
dc.description.abstract | Background & aims: The antidiabetic efficacy of turnip (Brassica rapa) roots ethanol extract (TE) was investigated in type 2 diabetic animals. Methods: C57BL/KsJ-db/db (db/db) mice and db/+ mice were used and the db/db mice were divided into control, TE (0.26g/100 g diet) and rosiglitazone (RG, 0.005 g/100 g diet) groups. Results: Despite hyperinsulinemia, the glucokinase activity was lower in the liver of the db/db mice than the db/+ mice, while the glucose-6-phosphatase activity was higher. TE and RG improved the glucose and insulin tolerance and lowered the blood glycosylated hemoglobin, plasma insulin, C-peptide and glucagon levels as well as reversed these hepatic glucose regulating enzyme activities in db/db mice. TE also increased the insulin/glucagon ratio and hepatic glycogen content. The plasma free fatty acid and plasma and hepatic cholesterol and triglyceride levels were higher in the db/db mice than db/+ mice. Interestingly, TE and RG lowered these plasma and hepatic lipids, and simultaneously reduced the hepatic phosphatidate phosphohydrolase, HMG-CoA reductase, ACAT, β-oxidation and carnitine palmitoyl transferase activities. Furthermore, TE lowered the hepatic fatty acid synthase activity, hepatic lipid droplets accumulation, and adipose tissue weight and size. Conclusions: We suggest TE may exert an antidiabetic effect in type 2 diabetic mice by enhancing the glucose and lipid metabolism. | - |
dc.publisher | Elsevier | - |
dc.title | Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice = C57BL/KsJ-db/db마우스에서 글루코오스와 지질대사에 있어서 순무 주정추출물의 효과 | - |
dc.title.alternative | Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice | - |
dc.type | Article | - |
dc.citation.title | Clinical Nutrition | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 167 | - |
dc.citation.startPage | 158 | - |
dc.citation.volume | 27 | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 정은주 | - |
dc.contributor.alternativeName | 백남인 | - |
dc.contributor.alternativeName | 정해건 | - |
dc.contributor.alternativeName | 방면호 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 이경태 | - |
dc.contributor.alternativeName | 강영진 | - |
dc.contributor.alternativeName | 이미경 | - |
dc.contributor.alternativeName | 김혜진 | - |
dc.contributor.alternativeName | 여지영 | - |
dc.contributor.alternativeName | 최명숙 | - |
dc.identifier.bibliographicCitation | Clinical Nutrition, vol. 27, no. 1, pp. 158-167 | - |
dc.identifier.doi | 10.1016/j.clnu.2007.09.009 | - |
dc.subject.keyword | Brassica rapa | - |
dc.subject.keyword | Glucose regulating enzymes | - |
dc.subject.keyword | Glucose tolerance | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | Lipid regulating enzymes | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.subject.local | brassica rapa | - |
dc.subject.local | Brassica rapa | - |
dc.subject.local | glucose regulating enzymes | - |
dc.subject.local | Glucose regulating enzymes | - |
dc.subject.local | Glucose tolerance | - |
dc.subject.local | glucose tolerance | - |
dc.subject.local | Insulin resistance | - |
dc.subject.local | insulin resistance | - |
dc.subject.local | Lipid regulating enzymes | - |
dc.subject.local | Type 2 diabetes | - |
dc.subject.local | Type 2 Diabetes | - |
dc.description.journalClass | Y | - |
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