Innate immune homeostasis by the homeobox gene Caudal and commensal-gut mutualism in Drosophila

Cited 578 time in scopus
Metadata Downloads
Title
Innate immune homeostasis by the homeobox gene Caudal and commensal-gut mutualism in Drosophila
Author(s)
J H Ryu; S H Kim; H Y Lee; J Y Bai; Young Do Nam; Jin-Woo Bae; D G Lee; S C Shin; E M Ha; W J Lee
Bibliographic Citation
Science, vol. 319, no. 5864, pp. 777-782
Publication Year
2008
Abstract
Although commensalism with gut microbiota exists in all metazoans, the host factors that maintain this homeostatic relationship remain largely unknown. We show that the intestinal homeobox gene Caudal regulates the commensal-gut mutualism by repressing nuclear factor kappa B-dependent antimicrobial peptide genes. Inhibition of Caudal expression in flies via RNA interference led to overexpression of antimicrobial peptides, which in turn altered the commensal population within the intestine. In particular, the dominance of one gut microbe, Gluconobacter sp. strain EW707, eventually led to gut cell apoptosis and host mortality. However, restoration of a healthy microbiota community and normal host survival in the Caudal-RNAi flies was achieved by reintroduction of the Caudal gene. These results reveal that a specific genetic deficiency within a host can profoundly influence the gut commensal microbial community and host physiology.
ISSN
0036-8075
Publisher
Amer Assoc Advancement Science
DOI
http://dx.doi.org/10.1126/science.1149357
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.