Ohioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum

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dc.contributor.authorC Seo-
dc.contributor.authorY H Choi-
dc.contributor.authorJ H Sohn-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorJ H Yim-
dc.contributor.authorH K Lee-
dc.contributor.authorH Oh-
dc.date.accessioned2017-04-19T09:09:06Z-
dc.date.available2017-04-19T09:09:06Z-
dc.date.issued2008-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2007.11.036ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8297-
dc.description.abstractOhioensins F and G (1 and 2), two new benzonaphthoxanthenones, have been isolated from the MeOH extract of Antarctic moss Polytrichastrum alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. The known compounds ohioensins A and C (3 and 4) were also obtained. Compounds 1-4 showed potent inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B). Kinetic analysis of PTP1B inhibition by ohioensin F (1) suggested that benzonaphthoxanthenones inhibited PTP1B activity in a non-competitive manner.-
dc.publisherElsevier-
dc.titleOhioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum-
dc.title.alternativeOhioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number2-
dc.citation.endPage775-
dc.citation.startPage772-
dc.citation.volume18-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName서찬건-
dc.contributor.alternativeName최윤혁-
dc.contributor.alternativeName손재학-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName임정한-
dc.contributor.alternativeName이홍금-
dc.contributor.alternativeName오현철-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 18, no. 2, pp. 772-775-
dc.identifier.doi10.1016/j.bmcl.2007.11.036-
dc.subject.keywordBenzonaphthoxanthenones-
dc.subject.keywordNon-competitive inhibitor-
dc.subject.keywordPolytrichastrum alpinum-
dc.subject.keywordProtein tyrosine phosphatase 1B (PTP1B)-
dc.subject.localBenzonaphthoxanthenones-
dc.subject.localNon-competitive inhibitor-
dc.subject.localnon-competitive inhibitors-
dc.subject.localNon-competitive inhibitors-
dc.subject.localnon-competitive inhibitor-
dc.subject.localPolytrichastrum alpinum-
dc.subject.localprotein tyrosine phosphatase 1B-
dc.subject.localprotein tyrosine phosphatase-1B (PTP1B)-
dc.subject.localProtein tyrosine phosphatase 1B-
dc.subject.localprotein tyrosine phosphatase 1B (PTP1B)-
dc.subject.localprotein tyrosine phosphatase 1B (FTPIB)-
dc.subject.localProtein tyrosine phosphatase 1B (PTP1B)-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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