Chromen-based TNF-α converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | K Chun | - |
| dc.contributor.author | Song Kyu Park | - |
| dc.contributor.author | Hwan Mook Kim | - |
| dc.contributor.author | Y Choi | - |
| dc.contributor.author | M H Kim | - |
| dc.contributor.author | C H Park | - |
| dc.contributor.author | B Y Joe | - |
| dc.contributor.author | T G Chun | - |
| dc.contributor.author | H M Choi | - |
| dc.contributor.author | H Y Lee | - |
| dc.contributor.author | S H Hong | - |
| dc.contributor.author | M S Kim | - |
| dc.contributor.author | K Y Nam | - |
| dc.contributor.author | G Han | - |
| dc.date.accessioned | 2017-04-19T09:09:06Z | - |
| dc.date.available | 2017-04-19T09:09:06Z | - |
| dc.date.issued | 2008 | - |
| dc.identifier.issn | 0968-0896 | - |
| dc.identifier.uri | 10.1016/j.bmc.2007.09.014 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8298 | - |
| dc.description.abstract | A series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-α, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system. | - |
| dc.publisher | Elsevier | - |
| dc.title | Chromen-based TNF-α converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation | - |
| dc.title.alternative | Chromen-based TNF-α converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry | - |
| dc.citation.number | 1 | - |
| dc.citation.endPage | 535 | - |
| dc.citation.startPage | 530 | - |
| dc.citation.volume | 16 | - |
| dc.contributor.affiliatedAuthor | Song Kyu Park | - |
| dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
| dc.contributor.alternativeName | 전광우 | - |
| dc.contributor.alternativeName | 박성규 | - |
| dc.contributor.alternativeName | 김환묵 | - |
| dc.contributor.alternativeName | 최용석 | - |
| dc.contributor.alternativeName | 김명화 | - |
| dc.contributor.alternativeName | 박춘호 | - |
| dc.contributor.alternativeName | 제보영 | - |
| dc.contributor.alternativeName | 전태규 | - |
| dc.contributor.alternativeName | 최현무 | - |
| dc.contributor.alternativeName | 이희윤 | - |
| dc.contributor.alternativeName | 홍성희 | - |
| dc.contributor.alternativeName | 김명숙 | - |
| dc.contributor.alternativeName | 남계엽 | - |
| dc.contributor.alternativeName | 한균희 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, vol. 16, no. 1, pp. 530-535 | - |
| dc.identifier.doi | 10.1016/j.bmc.2007.09.014 | - |
| dc.subject.keyword | coumarin derivatives | - |
| dc.subject.keyword | gelastatin hydroxamates | - |
| dc.subject.keyword | metalloproteinase-2 (MMP-2) | - |
| dc.subject.keyword | metalloproteinase-9 (MMP-9) | - |
| dc.subject.keyword | rheumatoid arthritis (RA) | - |
| dc.subject.keyword | TNF-α converting enzyme (TACE) | - |
| dc.subject.local | coumarin derivatives | - |
| dc.subject.local | gelastatin hydroxamates | - |
| dc.subject.local | metalloproteinase-2 (MMP-2) | - |
| dc.subject.local | metalloproteinase-9 (MMP-9) | - |
| dc.subject.local | metalloproteinase-9 | - |
| dc.subject.local | Rheumatoid Arthritis | - |
| dc.subject.local | Rheumatoid arthritis | - |
| dc.subject.local | rheumatoid arthritis (RA) | - |
| dc.subject.local | rheumatoid arthritis | - |
| dc.subject.local | TNFα converting enzyme | - |
| dc.subject.local | TNF-α converting enzyme (TACE) | - |
| dc.description.journalClass | Y | - |
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