Activation of PKCβII and PKCθ is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation

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dc.contributor.authorKyung Sun Heo-
dc.contributor.authorDong Uk Kim-
dc.contributor.authorL Kim-
dc.contributor.authorMiyoung Nam-
dc.contributor.authorSeung-Tae Baek-
dc.contributor.authorSong Kyu Park-
dc.contributor.authorYoung Woo Park-
dc.contributor.authorC S Myung-
dc.contributor.authorS O Hwang-
dc.contributor.authorKwang Lae Hoe-
dc.date.accessioned2017-04-19T09:09:07Z-
dc.date.available2017-04-19T09:09:07Z-
dc.date.issued2008-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2008.01.050ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8302-
dc.description.abstractNative LDL may be a mitogenic stimulus of VSMC proliferation in lesions where endothelial disruption occurs. Recent studies have demonstrated that the mitogenic effects of LDL are accompanied by Erk1/2 activation via an unknown G-protein-coupled receptor (GPCR). In this article, we report that LDL translocated PKCβII and PKCθ from cytosol to plasma membrane, and inhibition of PKCβII and PKCθ decreased LDL effects via the deactivation of Erk1/2. Moreover, pertussis toxin, but not cholera toxin or heparin, inhibited LDL-induced translocation of PKCβII and PKCθ, suggesting that Gi protein plays a role in LDL effects. of LPA, S1P, and LDL, whose signaling is conveyed via Gi/o proteins, only LDL induced translocation of PKCβII and PKCθ. Inhibition of PKCβII or PKCθ, as well as of Erk1/2 and GPCR, decreases LDL-induced upregulation of Egr-1, which is critical for cell proliferation. This is the first report, to our knowledge, that the participation of PKCθ in VSMC proliferation is unique.-
dc.publisherElsevier-
dc.titleActivation of PKCβII and PKCθ is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation-
dc.title.alternativeActivation of PKCβII and PKCθ is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage131-
dc.citation.startPage126-
dc.citation.volume368-
dc.contributor.affiliatedAuthorKyung Sun Heo-
dc.contributor.affiliatedAuthorDong Uk Kim-
dc.contributor.affiliatedAuthorMiyoung Nam-
dc.contributor.affiliatedAuthorSeung-Tae Baek-
dc.contributor.affiliatedAuthorSong Kyu Park-
dc.contributor.affiliatedAuthorYoung Woo Park-
dc.contributor.affiliatedAuthorKwang Lae Hoe-
dc.contributor.alternativeName허경선-
dc.contributor.alternativeName김동욱-
dc.contributor.alternativeName김리라-
dc.contributor.alternativeName남미영-
dc.contributor.alternativeName백승태-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName박영우-
dc.contributor.alternativeName명창선-
dc.contributor.alternativeName황성옥-
dc.contributor.alternativeName허광래-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 368, no. 1, pp. 126-131-
dc.identifier.doi10.1016/j.bbrc.2008.01.050-
dc.subject.keywordEgr-1-
dc.subject.keywordErk1/2 MAPK-
dc.subject.keywordGPCR-
dc.subject.keywordLow-density lipoprotein-
dc.subject.keywordPKC-
dc.subject.keywordSmooth muscle cell-
dc.subject.localEGR1-
dc.subject.localEgr-1-
dc.subject.localEGR-1-
dc.subject.localErk1/2 MAPK-
dc.subject.localGPCRs-
dc.subject.localGPCR-
dc.subject.localLow-density lipoprotein-
dc.subject.locallow-density lipoproteins-
dc.subject.localLow-density lipoprotein (LDL)-
dc.subject.localLow-density lipoproteins-
dc.subject.locallow-density lipoprotein-
dc.subject.localPKC-
dc.subject.localSmooth muscle cell-
dc.subject.localsmooth muscle cell-
dc.description.journalClassY-
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Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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