DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kyung Sun Heo | - |
dc.contributor.author | Dong Uk Kim | - |
dc.contributor.author | L Kim | - |
dc.contributor.author | Miyoung Nam | - |
dc.contributor.author | Seung-Tae Baek | - |
dc.contributor.author | Song Kyu Park | - |
dc.contributor.author | Young Woo Park | - |
dc.contributor.author | C S Myung | - |
dc.contributor.author | S O Hwang | - |
dc.contributor.author | Kwang Lae Hoe | - |
dc.date.accessioned | 2017-04-19T09:09:07Z | - |
dc.date.available | 2017-04-19T09:09:07Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | 10.1016/j.bbrc.2008.01.050 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8302 | - |
dc.description.abstract | Native LDL may be a mitogenic stimulus of VSMC proliferation in lesions where endothelial disruption occurs. Recent studies have demonstrated that the mitogenic effects of LDL are accompanied by Erk1/2 activation via an unknown G-protein-coupled receptor (GPCR). In this article, we report that LDL translocated PKCβII and PKCθ from cytosol to plasma membrane, and inhibition of PKCβII and PKCθ decreased LDL effects via the deactivation of Erk1/2. Moreover, pertussis toxin, but not cholera toxin or heparin, inhibited LDL-induced translocation of PKCβII and PKCθ, suggesting that Gi protein plays a role in LDL effects. of LPA, S1P, and LDL, whose signaling is conveyed via Gi/o proteins, only LDL induced translocation of PKCβII and PKCθ. Inhibition of PKCβII or PKCθ, as well as of Erk1/2 and GPCR, decreases LDL-induced upregulation of Egr-1, which is critical for cell proliferation. This is the first report, to our knowledge, that the participation of PKCθ in VSMC proliferation is unique. | - |
dc.publisher | Elsevier | - |
dc.title | Activation of PKCβII and PKCθ is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation | - |
dc.title.alternative | Activation of PKCβII and PKCθ is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation | - |
dc.type | Article | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 131 | - |
dc.citation.startPage | 126 | - |
dc.citation.volume | 368 | - |
dc.contributor.affiliatedAuthor | Kyung Sun Heo | - |
dc.contributor.affiliatedAuthor | Dong Uk Kim | - |
dc.contributor.affiliatedAuthor | Miyoung Nam | - |
dc.contributor.affiliatedAuthor | Seung-Tae Baek | - |
dc.contributor.affiliatedAuthor | Song Kyu Park | - |
dc.contributor.affiliatedAuthor | Young Woo Park | - |
dc.contributor.affiliatedAuthor | Kwang Lae Hoe | - |
dc.contributor.alternativeName | 허경선 | - |
dc.contributor.alternativeName | 김동욱 | - |
dc.contributor.alternativeName | 김리라 | - |
dc.contributor.alternativeName | 남미영 | - |
dc.contributor.alternativeName | 백승태 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.contributor.alternativeName | 박영우 | - |
dc.contributor.alternativeName | 명창선 | - |
dc.contributor.alternativeName | 황성옥 | - |
dc.contributor.alternativeName | 허광래 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 368, no. 1, pp. 126-131 | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.01.050 | - |
dc.subject.keyword | Egr-1 | - |
dc.subject.keyword | Erk1/2 MAPK | - |
dc.subject.keyword | GPCR | - |
dc.subject.keyword | Low-density lipoprotein | - |
dc.subject.keyword | PKC | - |
dc.subject.keyword | Smooth muscle cell | - |
dc.subject.local | EGR1 | - |
dc.subject.local | Egr-1 | - |
dc.subject.local | EGR-1 | - |
dc.subject.local | Erk1/2 MAPK | - |
dc.subject.local | GPCRs | - |
dc.subject.local | GPCR | - |
dc.subject.local | Low-density lipoprotein | - |
dc.subject.local | low-density lipoproteins | - |
dc.subject.local | Low-density lipoprotein (LDL) | - |
dc.subject.local | Low-density lipoproteins | - |
dc.subject.local | low-density lipoprotein | - |
dc.subject.local | PKC | - |
dc.subject.local | Smooth muscle cell | - |
dc.subject.local | smooth muscle cell | - |
dc.description.journalClass | Y | - |
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