α-amylase and protein tyrosine phosphatase 1B inhibitory of some Vietnamese medicinal plants used to treat diabetes

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Title
α-amylase and protein tyrosine phosphatase 1B inhibitory of some Vietnamese medicinal plants used to treat diabetes
Author(s)
T M Hung; H D Manh; P T H Minh; U J Youn; Min Kyun Na; Won Keun Oh; B S Min; K Bae
Bibliographic Citation
Natural Products Sciences, vol. 13, no. 4, pp. 311-316
Publication Year
2007
Abstract
In this study, the twenty-four ethyl acetate extracts of twenty-two medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for α-amylase and protein tyrosine phosphatase 1B (PTP1B) enzymes inhibitory activity in vitro. The results indicated that, twelve materials (50.0%) showed moderate to strong inhibitory activity in α-amylase inhibitory activity with IC50 values ranging from 2.5 to 48.8 μg/mL; meanwhile, ten extracts (41.6%) could demonstrate PTP1B activity with IC50 values less than 30.5 μg/mL. Some plants presented interesting activities against both of α-amylase and PTP1B enzymes such as Catharanthus roseus, Carthamus tinctorius, Momordica charantia, Gynostemma pentaphyllum, Glycyrrhiza glabra, Smilax glabra, Psidium guajava (leave), and Rehmannia glutinosa. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants.
Keyword
α-amylasediabetesprotein tyrosine phosphatase 1Bvietnamese medicinal plants
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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