TNFR1 promoter -329G/T polymorphism results in allele-specific repression of TNFR1 expression

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Title
TNFR1 promoter -329G/T polymorphism results in allele-specific repression of TNFR1 expression
Author(s)
S Kim; S M Moon; Yong Sung Kim; J J Kim; H J Ryu; Y J Kim; J W Choi; Hong-Seog Park; D G Kim; H D Shin; M S Rutherford; B Oh; J K Lee
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 368, no. 2, pp. 395-401
Publication Year
2008
Abstract
Tumor necrosis factor (TNF) and the TNF receptor (TNFR) superfamily play very important roles for cell death as well as normal immune regulation. Dysregulation of TNF-TNFR superfamily gene expression will influence many biological processes, and contributes to human diseases, including cancer. We investigated the genetic alterations of the TNF-TNFR superfamily genes in hepatocellular carcinoma (HCC). Several genetic alterations were detected in the 44 TNF-TNFR superfamily genes by sequencing hepatocellular carcinoma DNA samples. In particular, we found that the TNFR1 promoter -329G/T polymorphism was strongly associated with primary HCC (odds ratio [OR] = 5.22, p = 0.0007). We also observed frequent loss of heterozygosity at the polymorphic TNFR1 -329G/T site in the primary tumor tissues, indicating that the polymorphic TNFR1 -329G/T site is very susceptible to genetic alterations in HCC. Furthermore, in the polymorphic TNFR1 -329G/T site, the T allele resulted in the repression of TNFR1 expression. Therefore, our results suggest that TNFR1 -329G/T polymorphism may play an important role in the development of HCC.
Keyword
hepatocellular carcinomapromotersingle nucleotide polymorphism (SNP)TNFR1
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2008.01.098
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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